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Response to azathioprine in ulcerative colitis

Report of 7 cases


Ulcerative colitis is considered to be the result of an immunopathological reaction in the wall of the colon. Hence 7 patients with ulcerative colitis, including 2 with extracolonic features, were treated with the immunosuppressive drugs 6-mercaptopurine and azathioprine, mostly on a long-term basis. Six of the 7 patients showed varying degrees of clinical improvement. The most noteworthy effect was a striking decrease in lymphoid infiltration in the rectal mucosa.

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We are indebted to Dr. George Hitchings and Dr. Gertrude Elion of the Wellcome Research Laboratories, Burroughs Wellcome & Co. (U.S.A.) Inc., for generous supplies of azathioprine (Imuran).

Aided by a grant from The National Health and Medical Research Council of Australia.

Drug Houses of Australia Fellow for 1964.

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Mackay, I.R., Wall, A.J. & Goldstein, G. Response to azathioprine in ulcerative colitis. Digest Dis Sci 11, 536–545 (1966). https://doi.org/10.1007/BF02233565

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  • Public Health
  • Ulcerative Colitis
  • Clinical Improvement
  • Immunosuppressive Drug
  • Rectal Mucosa