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The American Journal of Digestive Diseases

, Volume 11, Issue 8, pp 648–651 | Cite as

Diphenidol, A new antiemetic: A double-blind, placebo-controlled study

  • Melvin D. Small
Article

Summary

Placebo or diphenidol, a new nonphenothiazine antiemetic, was given to 30 patients with severe nausea and vomiting due to conditions including uremia, metastatic cancer, and hepatic decompensation. Diphenidol provided relief from nausea and vomiting that was significantly greater than the relief provided by placebo (P<0.02 and P<0.02). In the dosage required to control the symptoms, diphenidol did not cause any side effects that interfered with other medical treatment. The antiemetic activity of diphenidol appeared to be equivalent to that of the phenothiazines. Moreover, in the recommended antiemetic doses, diphenidol did not cause any of the side effects that can occur with the phenothiazines. Finally, in doses higher than those recommended for antiemetic activity, diphenidol appeared to be useful in controlling prolonged, intractable singultus. This impression should be confirmed by controlled studies.

Keywords

Public Health Placebo Medical Treatment Uremia Phenothiazine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Berry, C, andMcConnell, J. P. Diphenidol.Roy. Army Med. Corps J. 3:46, 1965.Google Scholar
  2. 2.
    Borison, H. L., andWang, S. C. Physiology and pharmacology of vomiting.Pharm. Rev. 5:193, 1953.PubMedGoogle Scholar
  3. 3.
    Investigational Use Circular, Smith Kline & French Laboratories, Philadelphia, Pa., 1964.Google Scholar
  4. 4.
    Leonard, C. A., et al. Pharmacological effects of SK&F No. 478-A (diphenidol) α,α-diphenyl-1-piperidinebutanol HCl, a non-phenothiazine antiemetic agent.Pharmacologist 5:265, 1961.Google Scholar
  5. 5.
    Moyer, J. H. Effective antiemetic agents.Med. Clin. North America 41:405, 1957.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1966

Authors and Affiliations

  • Melvin D. Small
    • 1
    • 2
  1. 1.From the Gastroenterology ServiceGeorgetown University Medical DivisionUSA
  2. 2.the Department of MedicineGeorgetown University School of Medicine, Georgetown Medical Division, District of Columbia General HospitalWashington, D. C.

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