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Concentration and partial characterization of human salivary gastrone


An inhibitor of gastric-acid secretion has been purified from human saliva and its activity concentrated 30-fold. Inactive material has been removed from saliva by extraction into phenol, by digestion with protease, by heat precipitation, and by prolonged dialysis. The final preparation contained polysaccharide or mucopolysaccharide of molecular weight in excess of 100,000, as well as traces of sialic acid and protein.

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The authors wish to record their indebtedness to Drs. D. B. Morell, F. J. Radcliff, and J. Gagolski for their advice and encouragement with this study and to the Postgraduate Medical Foundation in the University of Sydney for generous financial support.

Research Fellow of the Royal Australasian College of Physicians.

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Baume, P.E., Baxter, C.H. & Nicholls, A. Concentration and partial characterization of human salivary gastrone. Digest Dis Sci 12, 965–972 (1967).

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  • Public Health
  • Precipitation
  • Molecular Weight
  • Phenol
  • Polysaccharide