The American Journal of Digestive Diseases

, Volume 13, Issue 7, pp 608–614 | Cite as

Anticholinergic drug action on pancreatic exocrine outflow in man and dog

  • H. Schapiro
  • L. D. Wruble
  • J. W. Estes
  • R. Sherman
  • L. G. Britt


The endogenous secretin mechanism in dogs and in man is very sensitive to low concentrations of anticholinergic drugs. The release of secretin may be blocked by very small doses of these anticholinergic drugs, but once secretin gets into the bloodstream, its action can only be partially blocked by very large concentrations of the anticholinergic drugs.


Public Health Drug Action Small Dose Secretin Large Concentration 
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  1. 1.
    Schapiro, H., andWoodward, E. R. Inhibition of secretin mechanism with local anesthetics.Physiologist 5:104, 1962.Google Scholar
  2. 2.
    Thomas, J. E., andSwena, E. M. The effect of local anesthetics applied to the intestinal mucosa on the response of the pancreas to intestinal stimuli.Fed Proc 22:664, 1964.Google Scholar
  3. 3.
    Preshaw, R. M., andGrossman, M. I. Stimulation of pancreatic secretion by extracts of the pyloric gland of the stomach.Gastroenterology 48:36, 1965.PubMedGoogle Scholar
  4. 4.
    Thomas, J. E. An improved cannula for gastric and intestinal fistulas.Proc Soc Exper Biol Med 46:260, 1941.Google Scholar
  5. 5.
    Mellanby, J. The mechanism of pancreatic digestion. The function of secretin.J Physiol 60:85, 1925.Google Scholar
  6. 6.
    Wang, C. C., andGrossman, M. I. Physiological determination of release of secretin and pancreozymin from intestine of dogs with transplanted pancreas.Amer J Physiol 164:527, 1951.PubMedGoogle Scholar
  7. 7.
    Magee, D. F., Fragola, L. A., andWhite, T. T. Influence of parasympathetic innervation on the volume of pancreatic juice.Ann Surg 161:15, 1965.PubMedGoogle Scholar
  8. 8.
    Thomas, J. E., andCrider, J. O. The secretion of pancreatic juice in the presence of atropine or hyoscyamine in chronic fistula dogs.J Pharmacol Exp Ther 87:81, 1946.Google Scholar
  9. 9.
    Thomas, J. E. Mechanism of action of pancreatic stimuli studied by means of atropinelike drugs.Amer J Physiol 206:124, 1964.PubMedGoogle Scholar
  10. 10.
    Anderson, M. D., Mehn, W. H., andMethod, H. L. Physiologic observations upon a partial pancreatic fistula following gastrectomy.Amer J Surg 97:260, 1959.CrossRefPubMedGoogle Scholar
  11. 11.
    Elmslie, R. G., White, T. T., andMagee, D. F. Observation on pancreatic function in eight patients with controlled pancreatic fistulas.Ann Surg 160:937, 1964.PubMedGoogle Scholar
  12. 12.
    Mahaffey, J. H., andHaynes, B. W. Jr. Observations on pancreatic juice in a case of external fistula in man.Amer Surg 19:174, 1953.Google Scholar
  13. 13.
    Miller, J. M., andGinsburg, M. Physiologic observations on a patient with an external fistula.Arch Surg (Chicago) 61:346, 1950.Google Scholar
  14. 14.
    Comfort, M. W., Osterbug, A. E., andPriestley, J. T. External pancreatic fistula: Report of a case with physiologic observations.Amer J Dig Dis 10:7, 1943.Google Scholar
  15. 15.
    Hirota, M. Post-gastrectomy pancreatic secretion: experimental observation on a case of the external pancreatic fistula in man.Yokohama Med Bull 9:187, 1958.PubMedGoogle Scholar
  16. 16.
    Howard, J. M., Evans, S. S., andJames, C. L. Effects of banthine on the external pancreatic secretion in man.Ann Surg 135:91, 1952.PubMedGoogle Scholar
  17. 17.
    McCaughan, J. M., Sinner, B. L., andSullivan, C. J. The external secretory function of the human pancreas.Arch Intern Med (Chicago) 61:739, 1938.Google Scholar
  18. 18.
    Miller, J. M., andWiper, T. B. Physiologic observations on patients with external pancreatic fistula.Ann Surg 120:852, 1944.Google Scholar
  19. 19.
    Newman, E. A., andEisenstein, M. Obervations on a patient with pancreatic fistula.Gastroenterology 13:528, 1949.PubMedGoogle Scholar
  20. 20.
    Rumore, P. C., Olander, G. A., andPuestow, C. B. Excretion of antibiotics, dyes and radioactive substances through external pancreatic fistula.Surgery 34:735, 1953.PubMedGoogle Scholar
  21. 21.
    Sinclair, I. S. R. Observations on a case of external pancreatic fistula in man.Brit J Surg 44:250, 1956.PubMedGoogle Scholar
  22. 22.
    Snyder, W. H., andLium, R. Pancreatic fistula.Surg Gynec Obstet 62:57, 1936.Google Scholar
  23. 23.
    Baker, R. J., Bass, R. T., Zajtchuk, R., andStrohl, E. L. External pancreatic fistula following abdominal injury.Arch Surg (Chicago) 95:556, 1967.Google Scholar
  24. 24.
    Doubilet, H., andFishman, L. Human biliary-pancreatic secretion.Amer J Gastroent 35:499, 1961.PubMedGoogle Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1968

Authors and Affiliations

  • H. Schapiro
    • 1
  • L. D. Wruble
    • 1
  • J. W. Estes
    • 1
  • R. Sherman
    • 1
  • L. G. Britt
    • 1
  1. 1.From the Department of Anatomy, College of Basic Medical Sciences and Departments of Medicine (Division of Gastroenterology) and SurgeryUniversity of Tennessee Medical UnitsMemphis

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