Differential response to various stimulants in the body and antrum of the canine stomach
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This study was initiated to evaluate gastric motility with the use of extraluminal force transducers in unanesthetized dogs. The contractile activity of the circular and longitudinal muscle in both antrum and body of the canine stomach was monitored in the interdigestive state and under the influence of food, acetylcholine, and 5-hydroxytryptophane. The latter two chemicals were infused for a 30-min. period. Each of the two muscle layers in antrum and body had a maximum frequency of 5 contractions per minute. This activity was continuous during 30 min. only under the influence of food and 5-hydroxytryptophane. Acetylcholine stimulant effects did not persist beyond the initial 10 min. of infusion. Amplitude of contractions under spontaneous or induced activity varied. The height of these contractions were circular antrum > longitudinal antrum > circular body > longitudinal body. This method of recording muscle contractility is believed to be useful for quantitatively assaying gastric activity without compromise of physiologic environment.
KeywordsPublic Health Acetylcholine Muscle Layer Differential Response Maximum Frequency
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- 1.Hightower, N. C., Code, C. F., andMaher, F. T. A method for the study of gastrointestinal motor activity in human beings.Proc Mayo Clin 24:453, 1949.Google Scholar
- 4.Brody, D. A., andQuigley, J. P. Application of the “inductograph” to the registration of movements, particularly of body structures such as the pyloric sphincter.J Lab Clin Med 29:863, 1944.Google Scholar
- 5.Jacoby, H. I., Bass, P., andBennett, D. R. In vivo extraluminal contractile force transducer for gastrointestinal muscle.J Appl Physiol 18:658, 1963.Google Scholar
- 6.Ludwick, J. R., andBass, P. Contractile and electric activity of the extrahepatic biliary tract and duodenum.Surg Gynec Obstet 124:534, 1967.Google Scholar
- 7.Blouin, L. T., andPotoczak, R. A simple technique to prevent aortic rupture following implant of chronic flow probes.IEEE Trans Biomed Engin 14:56, 1967.Google Scholar
- 11.Martinson, J. Studies on the efferent vagal control of the stomach.Acta Physiol Scand 65 (Suppl. 255):5. 1965.Google Scholar
- 12.Haverback, B. J., andWirtschafter, S. K. “The Gastrointestinal Tract and Naturally Occurring Pharmacologically Active Amines.” InAdvances in Pharmacology (Vol. 1), Garattini, S., and Shore, P. A., Eds. Acad. Press, New York, 1962, pp. 309–348.Google Scholar
- 13.Misiewicz, J. J., Waller, S. L., andEisnet, M. Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro.Gut 7:208. 1966.Google Scholar