An anticholinergic drug, propantheline bromide, was administered orally and parenterally to Wistar rats for periods of up to 7 months. Gastric acid secretion, measured 48 hr. after discontinuance of the drug, was unchanged in rats that received propantheline orally and increased in those that received the drug parenterally. This increase was associated with greater thickness and surface area of fundic mucosa and reduced weight gain. The development of tolerance to propantheline did not occur.
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Hunt, J. N., andWales, R. C. Progress in patients with peptic ulceration treated for more than five years with poldine, including a double blind study.Brit Med J 2:13, 1966.
Dotevall, G., Walan, A., andWeinfeld, A. Effect of 1-hyoscyamine on gastric secretion of acid and intrinsic factor in man.Gut 8:276, 1967.
Card, W. I., andMarks, I. N. The relationship between the acid output of the stomach following “maximal” histamine stimulation and the parietal cell mass.Clin Sci 19:147, 1960.
Posey, E. L., Jr., Elliott, R., Aldridge, J., Turner, C., andFranklin, H. Long-term anticholinergic administration and gastric secretory function in dogs.Amer J Dig Dis 11:421, 1966.
Kowaleski, K., andKasper, T. Achlorhydria, gastric mucosal atrophy and gastric neoplastic lesions in rats, mice and hamsters treated with an anticholinergic drug, propantheline bromide, and a carcinogen, 20-methylcholanthrene.Canad J Surg 10:99, 1967.
Roe, J. H., andDwyer, H. M. Relation of nutrition to gastric function. 1. An experimental method.Proc Soc Exp Biol Med 41:603, 1939.
Kowaleski, K. Effect of prolonged administration of an anticholinergic drug on gastric secretion of rats, mice and hamsters.Arch Int Pharmacodyn 152:404, 1964.
Kowalfski, K. Effect of long-term treatment with an anticholinergic drug on gastric secretion in rats.Amer J Dig Dis 12:988, 1967.
Shay, H., Komarow, S. A., Fels, S. S., Mfranze, D., Gruenstein, M., andSiplet, H. A simple method for the uniform production of gastric ulceration in the rat.Gastroenterology 5:43, 1945.
Sircus, W. Prolonged augmentation of the maximal secretory responses of canine gastric pouches by chronic obstruction; a preliminary report and hypothesis.Amer J Dig Dis 10:499, 1965.
Crean, G. P. InGastric Secretion: Mechanisms and Control. Pergamon, Toronto, Canada, 1967. p. 33.
Barrett, A. M., Raventos, J., andSiddall, R. A. Influence of some anaesthetics on pharmacologically stimulated gastric secretion in the rat.Brit J Pharmacol 28:51, 1966.
Barrett, A. M. Specific stimulation of gastric acid secretion by a pentapeptide derivative of gastrin.J Pharm Pharmacol 18:633, 1966.
We are grateful to Mr. Ralph Marshall, Department of Medical Illustration, Cardiff Royal Infirmary, for carrying out the photography.
We should like to thank the Board of Governors of the United Cardiff Hospitals for a grant to one of us (A.J.).
Propantheline bromide (Pro-Banthīne) was generously supplied by G. D. Searle & Co. Ltd.
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Kaye, M.D., Jacobs, A., Ireson, H. et al. Effect of prolonged administration of an anticholinergic drug, propantheline bromide, on gastric histology and acid secretion. Digest Dis Sci 13, 994–1002 (1968). https://doi.org/10.1007/BF02232922
- Public Health
- Weight Gain
- Gastric Acid
- Acid Secretion