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Effect of prolonged administration of an anticholinergic drug, propantheline bromide, on gastric histology and acid secretion

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Summary

An anticholinergic drug, propantheline bromide, was administered orally and parenterally to Wistar rats for periods of up to 7 months. Gastric acid secretion, measured 48 hr. after discontinuance of the drug, was unchanged in rats that received propantheline orally and increased in those that received the drug parenterally. This increase was associated with greater thickness and surface area of fundic mucosa and reduced weight gain. The development of tolerance to propantheline did not occur.

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Additional information

We are grateful to Mr. Ralph Marshall, Department of Medical Illustration, Cardiff Royal Infirmary, for carrying out the photography.

We should like to thank the Board of Governors of the United Cardiff Hospitals for a grant to one of us (A.J.).

Propantheline bromide (Pro-Banthīne) was generously supplied by G. D. Searle & Co. Ltd.

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Kaye, M.D., Jacobs, A., Ireson, H. et al. Effect of prolonged administration of an anticholinergic drug, propantheline bromide, on gastric histology and acid secretion. Digest Dis Sci 13, 994–1002 (1968). https://doi.org/10.1007/BF02232922

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Keywords

  • Public Health
  • Bromide
  • Weight Gain
  • Gastric Acid
  • Acid Secretion