Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Myxedema and intestinal malabsorption (nontropical sprue?) with severe hypo motility of the gastrointestinal tract

Report of a case

Summary

A case of malabsorption syndrome developing in a 43-year-old woman with primary hypothyroidism is reported. Her major symptoms were related to severe hypomotility of the gastrointestinal tract and impaired intestinal absorption. The generalized failure of propulsive action of the gut was probably secondary to both the thyroid and intestinal disease. There is a possibility that development of myxedema precipitated manifestations of overt sprue in a predisposed person with hitherto unrecognized latent sprue.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Kelley, M. L., Jr., Charles, R. N., andCampeti, F. L. A method for obtaining mucosal biopsy, measurement of enzyme activity, intraluminal pressures and cinefluorographic studies by a single intubation of the small bowel. Unpublished observations.

  2. 2.

    Bossak, E. T., Wang, C. I., andAdlersberg, D. “Clinical Aspects of the Malabsorption Syndrome.” InThe Malabsorption Syndrome, edited by D. Adlersberg, Grune, New York, 1957.

  3. 3.

    Green, P. A., andWollaeger, E. E. “The Clinical Behavior of Sprue in the United States.” InProceedings of World Congress of Gastroenterology, Washington, D. C. 1958. Williams and Wilkins, Baltimore, Md.

  4. 4.

    Kelley, M. L., Jr., andTerry, R. Clinical and histological observations in fatal nontropical sprue.Am. J. Med. 25: 460, 1958.

  5. 5.

    Williams, R. H. Textbook of Endocrinology. Saunders, Philadelphia, 1962.

  6. 6.

    Hillemand, P., andBarré, Y. Dystonies digestives et desequilibres endocriniens.Semaine hôp. Paris 36: 30, 1960.

  7. 7.

    Marshak, R. H., Wolf, B. S., andEllasoph, J. “The Roentgen Findings in the Malabsorption Syndrome.” InThe Malabsorption Syndrome, edited by D. Adlersberg. New York, Grune. 1957.

  8. 8.

    Code, C. F., Hightower, N. C., Jr., andMorlock, C. G. Motility of the alimentary canal in man.Am. J. Med. 13:328, 1952.

  9. 9.

    Ingelfinger, F. J. The diagnosis of sprue in nontropical areas.New England J. Med. 228:180, 1943.

  10. 10.

    Naish, J. M., Capper, W. M., andBrown, N. J. Intestinal pseudo-obstruction with steatorrhea.Gut 1:62, 1960.

  11. 11.

    Cooke, W. T., Peeney, A. L. P., andHawkins, C. F. Symptoms, signs and diagnostic features of idiopathic steatorrhea.Quart. J. Med. (N.S.) 22:59, 1953.

Download references

Author information

Additional information

Supported by Research Grant AM-04097 from the National Institute of Arthritis and Metabolic Diseases.

Appreciation is expressed to Dr. Roger Terry for interpretation of the duodenal biopsy and the photomicrograph and to Dr. Victor W. Logan and Dr. Eric E. Wollaeger for their helpful comments regarding the preparation of this report. We are indebted to Dr. James C. Harberson for the details of the operative findings. Determinations for plasma hydrocortisone and urinary corticoids were done by Dr. John E. Plager.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kelley, M.L., Stewart, J.M. Myxedema and intestinal malabsorption (nontropical sprue?) with severe hypo motility of the gastrointestinal tract. Digest Dis Sci 9, 79–86 (1964). https://doi.org/10.1007/BF02232684

Download citation

Keywords

  • Public Health
  • Gastrointestinal Tract
  • Hypo
  • Hypothyroidism
  • Intestinal Absorption