Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Newer horizons in the etiology of pancreatitis: Metabolic and endocrinologic factors

  • 14 Accesses

  • 7 Citations

Conclusions

1. Pancreatitis associated with alcoholism and biliary-tract disease account for etiology in only approximately two-thirds of the cases of chronic pancreatitis. The remainder comprise clinical varieties of pancreatitis of metabolic, vascular, and endocrinologic pathogenesis. These varieties are not as rare as previously thought.

2. Five case reports are presented illustrating silent, painless, hyperparathyroid-associated, hereditary-familial, and perhaps, hereditary-parathyroid-associated pancreatitis. The theoretical and clinical implications are discussed.

3. The importance of excluding parathyroid disease in all patients with pancreatic calculi is stressed.

4. A patient is presented who, in 7 years following sphincterotomy, has exhibited no roentgen, laboratory, or clinical evidence of deterioration of gallbladder function and no cholecystic inflammatory disease.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Bartholomew, L. G., andComfort, M. W. Chronic pancreatitis without pain.Proc. Staff Meet. Mayo Clin. 32:361, 1957.

  2. 2.

    Bartholomew, L. G. New concepts in pancreatic disease.Gastroenterology 36:122, 1959.

  3. 3.

    Cope, O., Culver, P. J., Mixter, C. G., andNardi, G. L. Pancreatitis: A diagnostic clue to hyperparathyroidism.Ann. Surg. 145:857, 1957.

  4. 4.

    Recant, L., andHartroft, W. S. Primary hyperparathyroidism, pancreatitis, and peptic ulcer.Am. J. Med. 23:953, 1957.

  5. 5.

    Jordan, G. L., Curd, G. W., Gyorkey, F., andDeBakey, M. E. Carcinoma of the parathyroid.A.M.A. Arch. Surg. 76:87, 1958.

  6. 6.

    Gross, J. B. Some recent developments pertaining to pancreatitis.Ann. Int. Med. 49:796, 1958.

  7. 7.

    Wang, C., Adlersberg, D., andFeldman, E. B. Serum lipids in acute pancreatitis.Gastroenterology 36:832, 1959.

  8. 8.

    Gross, J. B., andComfort, M. W. Chronic pancreatitis.Am. J. Med. 21:596, 1956.

  9. 9.

    Gross, J. B., Comfort, M. W., andWaugh, J. M. Painless single stone in pancreatic duct. Report of a case with steatorrheal diarrhea.Gastroenterology 32:126, 1957.

  10. 10.

    Peters, B. J., Lubitz, J. M., andLindert, M. C. F. Diffuse calcifications of the pancreas.A.M.A. Arch. Int. Med. 87:391, 1951.

  11. 11.

    Zuidema, P. J. Calcification and cirrhosis of pancreas in patients with deficient nutrition.Docum. Med. Geogr. Trop. Amst. 7:229, 1955; cited by McGeorge, B. P.,et al. Am. J. Roentgenol. 78:599, 1957.

  12. 12.

    Haverback, B. J., Bundy, H., andEdmondson, H. A. “The conversion of trypsinogen to trypsin in human pancreatic juice,” presented at the American Gastroenterological Association Annual Meeting at Atlantic City, N. J., June 1959.

  13. 13.

    Gross, J. B., Comfort, M. W., andUlrich, J. Abnormalities of serum and urinary amino acids in hereditary and non-hereditary pancreatitis.Tr. A. Am. Physicians 70:127, 1957.

  14. 14.

    Jackson, C. E. Hereditary hyperparathyroidism associated with recurrent pancreatitis.Ann. Int. Med. 49:829, 1959.

Download references

Author information

Additional information

The Secretin used in the study described in this article was provided by Eli Lilly Company, Inc., Indianapolis, Ind.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dreiling, D.A., Mazure, P.A., Cohen, N. et al. Newer horizons in the etiology of pancreatitis: Metabolic and endocrinologic factors. Digest Dis Sci 7, 112–126 (1962). https://doi.org/10.1007/BF02232666

Download citation

Keywords

  • Public Health
  • Pancreatitis
  • Inflammatory Disease
  • Chronic Pancreatitis
  • Clinical Implication