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Modification of the electrical activity of the human intestine after serotonin and caerulein

Abstract

The effects of serotonin and caerulein on the electrical activity of the human small intestine has been investigated. In a dose of 2.5 mg intravenuously, serotonin induces a strong motor response, with an increase in slow-wave amplitude (P<0.01) and a decrease in frequency (P<0.001). The percentage of bursts of spike, their duration and amplitude increased significantly (P<0.01 andP<0.05). The administration of caerulein (2 ng/kg/minute intravenously) inhibited spike percentage duration in the first and second portion of the duodenum, and a significant increase in the third and upper small intestine. Caerulein caused a significant decrease in slow-wave frquency (P<0.01) at every level. The possibility that the above substances have a direct effect on pace-setter potential is discussed. The purpose of the present investigation is to study the effect of serotonin* and caerulein* on the electrical activity in the human small intestine.

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Correspondence to G. A. Lanfranchi MD.

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Labo, G., Barbara, L., Lanfranchi, G.A. et al. Modification of the electrical activity of the human intestine after serotonin and caerulein. Digest Dis Sci 17, 363–372 (1972). https://doi.org/10.1007/BF02231739

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Keywords

  • Public Health
  • Direct Effect
  • Serotonin
  • Small Intestine
  • Electrical Activity