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Modification of the electrical activity of the human intestine after serotonin and caerulein


The effects of serotonin and caerulein on the electrical activity of the human small intestine has been investigated. In a dose of 2.5 mg intravenuously, serotonin induces a strong motor response, with an increase in slow-wave amplitude (P<0.01) and a decrease in frequency (P<0.001). The percentage of bursts of spike, their duration and amplitude increased significantly (P<0.01 andP<0.05). The administration of caerulein (2 ng/kg/minute intravenously) inhibited spike percentage duration in the first and second portion of the duodenum, and a significant increase in the third and upper small intestine. Caerulein caused a significant decrease in slow-wave frquency (P<0.01) at every level. The possibility that the above substances have a direct effect on pace-setter potential is discussed. The purpose of the present investigation is to study the effect of serotonin* and caerulein* on the electrical activity in the human small intestine.

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  1. 1.

    Labò G, Barbara L, Lanfranchi GA, Azzaroli P: L'elettroduodenogramma nell'uomo. Arch Ital Mal Appar Dig 34:384–396, 1967

  2. 2.

    Labò G, Barbara L, Lanfranchi GA, Bortolotti M, Miglioli M: The human intestine electrical activity. (In press).

  3. 3.

    Forster FM, Helm JD Jr, Ingelfinger FJ: The electric potentials of the human small intestine. Am J Physiol 139:433–437, 1943

  4. 4.

    Ono K, Narumi H, Watanabe N, Kumagai T, Suzuki K, Tsuchida H: Electromyographic study on movements of the human gastrointestinal tract using electrodes implanted in the bowel walls. Japan J Gastroenterology 1:22–26, 1964

  5. 5.

    Christensen J, Schedl HP, Clifton JA: The basic electrical rhythm of the duodenum in normal human subjects and in patients with thyroid disease. J Clin Invest 43:1659–1667, 1964

  6. 6.

    Christensen J, Schedl HP, Clifton JA: The small intestinal basic electric rhythm (slow wave) frequency gradient in normal men and in patients with a variety of diseases. Gastroenterology 50:309–315, 1966

  7. 7.

    Daniel EE, Carlow DR, Wechter BT, Sutherland WH, Bogoch A: Electrical activity of the small intestine. Gastroenterology 37:268–281, 1959

  8. 8.

    Monges H, Salducci J: Etude électromyographique de la motricité duodénale chez l'homme normal. Arch Fr Mal Appl Dig 59:19–28, 1970

  9. 9.

    Daniel EE, Honour AJ, Bogoch A: Antagonism of serotonin-induced contraction and electrical activity in the ileum. Gastroenterology 39:62–73, 1960

  10. 10.

    Besancon F: Le rôle physiologique de la sérotonine dans la motricité de l'intestin grêle humain. C R Soc Biol 154:1771–1776, 1960

  11. 11.

    Misiewicz JJ, Waller LS, Eisner M: Motor responses of human gastrointestinal tract to 5-HT “in vivo” and “in vitro”. Gut 7:208–216, 1966

  12. 12.

    Bertaccini G, Agosti A: Action of caerulein on intestinal motility in man. Gastroenterology 60:55–63, 1970

  13. 13.

    Ramorino ML, Ammaturo MV, Anzini F: Effects of caerulein on small and large bowel motility in man. Rendic R Gastroenterol 2:172–175, 1970

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Correspondence to G. A. Lanfranchi MD.

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Labo, G., Barbara, L., Lanfranchi, G.A. et al. Modification of the electrical activity of the human intestine after serotonin and caerulein. Digest Dis Sci 17, 363–372 (1972).

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  • Public Health
  • Direct Effect
  • Serotonin
  • Small Intestine
  • Electrical Activity