The effects of serotonin and caerulein on the electrical activity of the human small intestine has been investigated. In a dose of 2.5 mg intravenuously, serotonin induces a strong motor response, with an increase in slow-wave amplitude (P<0.01) and a decrease in frequency (P<0.001). The percentage of bursts of spike, their duration and amplitude increased significantly (P<0.01 andP<0.05). The administration of caerulein (2 ng/kg/minute intravenously) inhibited spike percentage duration in the first and second portion of the duodenum, and a significant increase in the third and upper small intestine. Caerulein caused a significant decrease in slow-wave frquency (P<0.01) at every level. The possibility that the above substances have a direct effect on pace-setter potential is discussed. The purpose of the present investigation is to study the effect of serotonin* and caerulein* on the electrical activity in the human small intestine.
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Labo, G., Barbara, L., Lanfranchi, G.A. et al. Modification of the electrical activity of the human intestine after serotonin and caerulein. Digest Dis Sci 17, 363–372 (1972). https://doi.org/10.1007/BF02231739
- Public Health
- Direct Effect
- Small Intestine
- Electrical Activity