Clinical Rheumatology

, Volume 15, Issue 1, pp 62–66 | Cite as

Multicentric reticulohistiocytosis

  • H. Kocanaogullari
  • H. Ozsan
  • F. Oksel
  • G. Ozturk
  • G. Kandiloglu
  • E. E. Ustun
  • E. Doganavsargil
Case Report


We describe a 42-year-old man with a five-year history of arthritis mutilans-like destructive joint changes and with a one-year history of nodules on the fingers, ears, oral mucosa, pharynx, larynx, vocal cords, some being ulcerated and haemorrhagic. He was diagnosed as having rheumatoid arthritis; however, biopsies from the nodules on the oral mucosa and ear revealed multicentric reticulohistiocytosis. The large nodule over the olecranon process, simulating a rheumatoid nodule but diagnosed as multicentric reticulohistiocytosis with biopsy; ulcerated and haemorrhagic nodules on the oral mucosa; and rapidly progressive joint destructions make our case interesting.

Key words

Multicentric Reticulohistiocytosis Destructive Polyarthritis Mucocutaneous Eruption Azathioprine 


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Copyright information

© Clinical Rheumatology 1996

Authors and Affiliations

  • H. Kocanaogullari
    • 1
  • H. Ozsan
  • F. Oksel
    • 1
  • G. Ozturk
    • 3
  • G. Kandiloglu
    • 2
  • E. E. Ustun
    • 4
  • E. Doganavsargil
    • 1
  1. 1.Division of Rheumatology, Department of MedicineEge UniversityBornova, IzmirTurkey
  2. 2.the Department of MedicineDivision of Pathology of the Ege University, School of MedicineIzmirTurkey
  3. 3.the Department of MedicineDivision of Dermatology of the Ege University, School of MedicineIzmirTurkey
  4. 4.the Department of MedicineDivision of Radiology of the Ege University, School of MedicineIzmirTurkey

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