Advertisement

Clinical Rheumatology

, Volume 12, Issue 3, pp 387–391 | Cite as

Correlation of interleukin-2 receptor and neopterin secretion in rheumatoid arthritis

  • W. Kullich
Originals

Summary

In rheumatoid arthritis (RA) an immuno dysregulation alters the release of neopterin from human monocytes/macrophages, probably by activation of a feed-back regulation mechanism in pterin metabolism. With the overactivation of T-lymphocytes, the secretion of interleukin-2 and its receptor (IL-2R) is influenced. Investigation on 84 RA patients has shown that this immunoactivation is accompanied by an increased secretion of neopterin and soluble IL-2R in the serum, and that both parameters are very suitable for detection of inflammatory disease activity. The significant correlation between neopterin and IL-2R (r=0.65; p≤0.001) in RA points out a possible connection in pathomechanisms of the immune system.

Key words

Interleukin-2 Receptor Neopterin Rheumatoid Arthritis Immunoregulation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Breedveld, F.C., De Vries, R.R.P. Possibilities for the immunotherapy of rheumatoid arthritis. Clin Rheumatol 1990, 9, 2, 171–175.CrossRefPubMedGoogle Scholar
  2. 2.
    Brückle, W. Neue Trends in der Basistherapie der chronischen Polyarthritis. Z Allg Med 1989, 65, 847–852.Google Scholar
  3. 3.
    Egg, D., Günther, R., Fuchs, D., Hausen, A., Reibnegger, G., Wachter, H. Neopterin, an indicator for activation of cellular immunity, in rheumatoid arthritis. In: Biochemical and Clinical Aspects of Pteridines. Eds.: Pfleiderer, W., Wachter, H., Curtius, H.C. Berlin-New York: Walter de Gruyter 1984, 3, 491–502.Google Scholar
  4. 4.
    Hannonen, P., Tikanoja, S., Hakola, M., Möttönen, T., Viinikka, L., Oka, M. Urinary neopterin index as a measure of rheumatoid activity. Scand J Rheumatol 1986, 15, 148–152.PubMedGoogle Scholar
  5. 5.
    Hausen, A., Fuchs, D., Reibnegger, G., Wachter, H. Neopterin as index for activity of disease in patients with rheumatoid arthritis. In: Biochemical and Clinical Aspects of Pteridins 2, Eds.: Verlag Walter de Gruyter & Co, 1983, 245–254.Google Scholar
  6. 6.
    Herzog, C., Walker, C.H., Pichler, W., Aeschlimann, A., Wassmer, P., Stockinger, H., Knapp, W., Rieber, P., Müller, W. Monoclonal anti-CD4 in arthritis. Lancet II 1987, 1461–1462.CrossRefGoogle Scholar
  7. 7.
    Herzog, C., Herzog, A., Aeschlimann, A., Gerber, H., Müller, W. Löslicher Interleukin-2-Rezeptor (sIL-2R) bei der chronischen Polyarthritis. Z Rheumatol 1990, 49, 8–10.PubMedGoogle Scholar
  8. 8.
    Huber, Ch., Fuchs, D., Hausen, A., Margreiter, R., Reibnegger, G., Spielberger, M., Wachter, H. Pteridines as a new marker to detect human T-cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants. J Immunol 1983, 130, 1047.PubMedGoogle Scholar
  9. 9.
    Huber, Ch., Fuchs, D., Niederwieser, D., Hausen, A., Reibnegger, G., Nilsson, K., Wachter, H. Neopterin, ein neuer biochemischer Marker zur klinischen Erfassung zellulärer Immunreaktionen. Klin Wochenschr 1984 62, 103–113.CrossRefPubMedGoogle Scholar
  10. 10.
    Huber, Ch., Batchelor, J.R., Fuchs, D., Hausen, A., Lang, A., Niederwieser, D., Reibnegger, G., Swetly, P., Troppmair, J., Wachter, H. Immune response-associated production of neopterin. J Exp Med 1984, 160, 310–316.CrossRefPubMedGoogle Scholar
  11. 11.
    Huber, Ch., Troppmair, J., Rokos, H., Curtius, H.C. Neopterin heute. Dtsch med Wschr 1987, 112, 107–113.PubMedGoogle Scholar
  12. 12.
    Keystone, E.C., Snow, K.M., Bombardier, C., Chang, C.-H., Nelson, D.L., Rubin, L.A. Elevated soluble interleukin-2 receptor levels in the sera and synovial fluids of patients with rheumatoid arthritis. Arthritis Rheum 1988, 31 (7), 844–849.PubMedGoogle Scholar
  13. 13.
    Krüger, K., Schattenkirchner, M. Pathogenetisch orientierte Therapieansätze in der Behandlung der chronischen Polyarthritis. Internist 1989, 30, 656–663.PubMedGoogle Scholar
  14. 14.
    Maerker-Alzer, G. Autoimmunreaktionen bei rheumatischen Erkrankungen. Internist 1990, 31, 19–25.Google Scholar
  15. 15.
    Maury, C.P.J., Andersson, L.C., Teppo, A.-M., Partanen, S., Juvonen, E. Mechanism of anaemia in rheumatoid arthritis: demonstration of raised interleukin 1β concentration in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro. Ann Rheum Dis 1988, 47, 972–978.PubMedGoogle Scholar
  16. 16.
    Ohlenschläger, G., Berger, I. Biochemische und klinische Betrachtungen zu den Immunmodulatoren: Interferone (IFN), Interleukin-2 (IL-2), Tumornekrose-Faktor (TNF) und dem Immunmarker Neopterin (Teil I) Biolog Medizin 1989, 4, 496–508.Google Scholar
  17. 17.
    Robb, R.J., Greene, W.C., Rusk, C.M. Low and high affinity receptors for IL-2. J Exp Med 1984, 160, 1126–1146.CrossRefPubMedGoogle Scholar
  18. 18.
    Roitt, I.M., Brostoff, J., Male, D.K. Kurzes Lehrbuch der Immunologie. Georg Thieme Verlag Stuttgart, New York, 1987.Google Scholar
  19. 19.
    Rokos, H., Bienhaus, G., Gadow, A., K. Rokos. Determination of neopterin and reduced neopterins by radioimmunoassay. In: Biochemical and Clinical Aspects of Pteridines. Eds.: Walter de Gruyter & Co, Berlin, New York, 1985, 4.Google Scholar
  20. 20.
    Symons, J.A., Wood, N.C., Di Giovine, F.S., Duff, G.W. Soluble IL-2 receptor in rheumatoid arthritis: Correlation with disease activity, IL-1 and IL-2 inhibition. J Immunol 1988, 141 (8), 2612–2618.PubMedGoogle Scholar
  21. 21.
    Verwilghen, J., Kingsley, G.H., Ceuppens, J.L., Panayi, G.S. Inhibition of synovial fluid T-cell proliferation by anti-CD5 monoclonal antibodies. Arthritis Rheum 1992, 36 (2), 1445–1451.Google Scholar
  22. 22.
    Vreugdenhil, G., Swaak, A.J.G. Anaemia in rheumatoid arthritis: pathogenesis, diagnosis and treatment. Rheumatol Int 1990, 9, 243–257.CrossRefPubMedGoogle Scholar
  23. 23.
    Wood, N.C., Symons, J.A., Duff, G.W. Serum interleukin-2 receptor in rheumatoid arthritis: A prognostic indicator of disease activity? J Autoimmun 1988, 1, 353–361.CrossRefGoogle Scholar
  24. 24.
    Ziegler, I., Hamm, U., Berndt, J. Participation of pterins in the control of lymphocyte stimulation and lymphoblast proliferation. Cancer Res 1983, 43, 5356–5359.PubMedGoogle Scholar

Copyright information

© Clinical Rheumatology 1993

Authors and Affiliations

  • W. Kullich
    • 1
  1. 1.Ludwig Boltzmann Institute for Rehabilitation of Internal DiseasesSaalfeldenAustria

Personalised recommendations