Clinical Rheumatology

, Volume 12, Issue 3, pp 375–380

Circulating intercellular adhesion molecules-1 and autoantibodies including anti-endothelial cell, anti-cardiolipin, and anti-neutrophil cytoplasma antibodies in patients with vasculitis

  • C. -R. Wang
  • M. -F. Liu
  • R. -T. Tsai
  • C. -Y. Chuang
  • C. -Y. Chen
Originals

DOI: 10.1007/BF02231583

Cite this article as:
Wang, C.R., Liu, M.F., Tsai, R.T. et al. Clin Rheumatol (1993) 12: 375. doi:10.1007/BF02231583

Summary

Circulating intercellular adhesion molecule-1 (ICAM-1) and 3 types of autoantibodies were measured in 30 patients with angiographical or pathological proved vasculitis. There were 18 patients with systemic vasculitis and 12 patients with cutaneous vasculitis. The measured antibodies included anti-endothelial cell antibodies (AECA), anti-cardiolipin (ACL) antibodies of 3 isotypes and anti-neutrophil cytoplasma antibodies (ANCA). The result showed that patients with systemic vasculitis had elevated levels of ICAM-1, AECA and IgG isotype antibody as compared with none or lower in patients with cutaneous vasculitis. Levels of ICAM-1 and IgG isotype ACL antibodies also decreased significantly after disease activity subsided in patients with systemic vasculitis. Measurement of ICAM-1 and autoantibodies may be useful in evaluating the extent of involvement and in following the disease activity of patients with vasculitis.

Key words

Vasculitis Circulating Adhesion Molecules-1 Autoantibody 

Copyright information

© Clinical Rheumatology 1993

Authors and Affiliations

  • C. -R. Wang
    • 1
  • M. -F. Liu
    • 2
  • R. -T. Tsai
    • 3
  • C. -Y. Chuang
    • 1
  • C. -Y. Chen
    • 1
  1. 1.Section of Rheumatology and Immunology, Department of Internal MedicineNational Taiwan University HospitalTaiwan, Republic of China
  2. 2.National Cheng-Kung University HospitalTaiwan, Republic of China
  3. 3.Chung Shan Medical and Dental College HospitalTaipeiTaiwan, Republic of China

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