1. Cobalt-60 teletherapy has been given to 72 patients with complicated peptic ulcer as a supplement to medical treatment.
2. The therapy was well tolerated with minimal reaction.
3. The treatment usually decreased the Histalog-stimulated and basal gastric acid secretion. There was a gradual return of hyperacidity in some patients in 6 to 12 months.
4. The initial symptomatic and roentgen response has been good in all patients. There was recurrence of symptoms, hyperacidity, and ulcer in 3 patients.
5. We feel that irradiation with cobalt-60 teletherapy may be indicated in many patients with complicated or so-called surgical ulcers, particularly in the bad-risk patients.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Bruegel, C. Cited by Ricketts, W. E., and associates.
Brown, C. H., andHays, R. A. Cobalt-60 teletherapy for complicated peptic ulcer: A preliminary report.Cleveland Clin. Quart. 24:17, 1957.
Brown, C. H. Complicated peptic ulcer treated by cobalt-60 teletherapy: A preliminary report of results in 34 patients.Henry Ford Hosp. Med. Bull. 5:276, 1957.
Brown, C. H., andHoerr, S. O. Treatment of duodenal ulcer.Postgrad. Med. 12:308, 1952.
Levin, E., Palmer, W. L., andKirsner, J. B. Observations on the diagnosis, treatment and course of gastric ulcer: Evaluation of gastric radiation as an adjunct in medical treatment.J. A. M. A. 156:1383, 1954.
Levin, E., Clayman, C. B., Palmer, W. L., andKirsner, J. B. Observations on the value of gastric radiation therapy in the treatment of duodenal ulcer.Gastroenterology 32:42, 1957.
McGeorge, M. Results of treatment of gastric hyperacidity by radium with special reference to duodenal ulceration.Quart. J. Med. 19:111, 1950.
Browne, G.,et al. Antroduodenectomy and x-ray radiation in treatment of duodenal ulcer.Lancet ii:1145, 1952.
Ricketts, W. E., Palmer, W. L., Kirsner, J. B., andHamann, A. Radiation therapy in peptic ulcer: Analysis of results.Gastroenterology 11:789, 1948.
Ricketts, W. E., Kirsner, J. B., Humphreys, E. M., andPalmer, W. L. Effect of roentgen radiation on gastric mucosa.Gastroenterology 11:818, 1948.
Kirsner, J. B., Levin, E., Palmer, W. L., andFord, H. Gastric secretory response to 3-beta aminoethyl pyrazole in man.Gastroenterology 20:138, 1952.
Levin, E., Kirsner, J. B., Palmer, W. L., andButler, C. Comparison of nocturnal gastric secretion in patients with duodenal ulcer and in normal individuals.Gastroenterology 10:952, 1948.
Dragstedt, L. R. The cause of peptic ulcer.J. A. M. A. 169:203, 1959.
Littman, A., Fox, B. W., Schoolman, H. M., andIvy, A. C. Lethal effect of intragastric radiation in the dog.Am. J. Physiol. 174:347, 1953.
Fox, B. W., Littman, A., Grossman, M., andIvy, A. C. Effect of intragastric radiation on gastric acidity in the Dog.Gastroenterology 24:517, 1953.
Littman, A. Personal communication, October, 1958.
Levin, E. Personal communication, Sept., 1959.
The radioactive material used in this study was supplied on authorization of the Isotopes Division, United States Atomic Energy Commission, Oak Ridge, Tenn.
About this article
Cite this article
Brown, C.H. Therapeutic principles in management of peptic ulcer. Digest Dis Sci 4, 1066–1072 (1959). https://doi.org/10.1007/BF02231507
- Public Health
- Medical Treatment
- Peptic Ulcer
- Gastric Acid
- Acid Secretion