In 12 of 18 studies on human gastric secretion a fall in free acid occurred after chlorothiazide was administered. In 3 of the 12 patients the decrease was definite, i.e., 60–100 per cent of basal secretion, in 4 the results equivocal, and in 5 the fall was not significant. The decrease in free acid was transient, lasting for 1 hour.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Janowitz, H. D., Dreiling, D. A., Rolbin, H. L., andHollander, F. Inhibition of the formation of hydrochloric acid in the human stomach by Diamox; The role of carbonic anhydrase in gastric secretion.Gastroenterology 33:378, 1957.
McGowen, J. A., Jr., Stanley, N. M., andPowell, J. J. The effect of 2-acetyl-amino-1, 3, 4-thiadiazole-5-sulfonamide (6063:Diamox) on the secretion of gastric hydrochloric acid in man.Bull. New England M. Center 14:117, 1952.
Merck, &Co., Inc. Research Laboratories, Rahway, N. J. Informational Summary on Diuril. February, 1958.
Beyer, K. H. The mechanism of action of chlorothiazide.Ann. New York Acad. Sc. 71:363, 1958.
Merck, & Co., Inc. Research Laboratories, Rahway, N. J. Informational Summary on Diuril. February, 1958.
Canosa, C., Kalkhof, K. C., andRehm, W. S. Diamox and Diuril stuies on stomach.Fed. Proc. 17:23, 1958.
Schales, O., andSchales, S. C. A simple and accurate method for the determination of chloride in biological fluids.J. Biol. Chem. 140:879, 1941.
Davenport, H. W. Gastric carbonic anhydrase.J. Physiol. 97:32, 1939.
Gray, J. S. The physiology of the parietal cell with special reference to the formation of acid.Gastroenterology 1:397, 1943.
Davenport, H. W. In memoriam: The carbonic anhydrase theory of gastric acid secretion.Gastroenterology 7:374, 1946.
Davies, R. E., andEdelman, J. The function of carbonic anhydrase in gastric mucosa.Biochem. J. 50:190, 1951.
Pitts, R. F., Hogben, C. A. M., Davenport, H. W., Davies, R. E., Rehm, W. S. Discussion. Secretion of Gastric Hydrochloric Acid. In Murphy, O. R.Metabolic Aspects of Transport Across Cell Membranes. Madison, Wis. Univ. Wisconsin Press, 1957, p. 331.
Davies, R. E. “Gastric hydrochloric Acid Production—The Present Position.” In Murphy, O. R.Metabolic Aspects of Transport Across Cell Membranes. Univ. Wisconsin Press, Madison, Wis. 1957, p. 277.
About this article
Cite this article
Kramer, P., Markarian, B. The effect of chlorothiazide on human gastric secretion. Digest Dis Sci 4, 130–136 (1959). https://doi.org/10.1007/BF02231233
- Public Health
- Free Acid
- Gastric Secretion
- Basal Secretion