Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Leucine aminopeptidase

Significance of serum elevations in disease of the hepato-biliary-pancreatic system

  • 59 Accesses

  • 21 Citations

This is a preview of subscription content, log in to check access.

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.


  1. 1.

    Linderstrøm-Lang, K.. Ueber Darmerepsin.Z. Physiol. Chem. 182:151–174, 1929.

  2. 2.

    Berger, J., andJohnson, M. J. The Occurrence of Leucylpeptidase.J. Biol. Chem. 133:157–172, 1940.

  3. 3.

    Fruton, J. S. On the Proteolytic Enzymes of Animal Tissues. V. Peptidase of the Skin, Lung and Serum.J. Biol. Chem. 166:721–738, 1946.

  4. 4.

    Smith, E. L. The Peptidases of Skeletal, Heart and Uterine Muscle.J. Biol. Chem. 173:553, 1948.

  5. 5.

    Johnson, M. J., Johnson, H. G. andPeterson, W. H. The Magnesium Activated Leucylpeptidase of Animal Erepsin.J. Biol. Chem. 116:515–526, 1936.

  6. 6.

    Smith, E. L. “Proteolytic Enzymes.”The Enzymes. Vol. 1, Part 2, p. 810–814 Academic Press Inc. N. Y., 1951. Jas. B. Sumner and Karl Myrback Editors.

  7. 7.

    Green, M. N., andKwan-Chung Tsou, Bressler, R., andSeligman, A. M. The Colorimetric Determination of Leucine Amino-Peptidase Activity with L-Leucyl β-Naphthyl-Amide Hydrochloride.Arch. Bio. Chem. & Biophys. 57:458–474, 1955.

  8. 8.

    Goldbarg, J. A., andRutenburg, A. M. Colormetric Determination of Leucine Amino-Peptidase in Urine and Serum of Normal Subjects and Patients with Cancer and other Diseases.Cancer 11:283–291, 1958.

  9. 9.

    Rutenburg, A. M., Goldbarg, J. A., andPineda, E. P. Leucine Amino-Peptidase Activity. Observations in Patients with Cancer of the Pancreas and other Diseases.N. Eng. J. Med. 259:469–472, 1958.

  10. 10.

    Fleischer, G. A., Butt, H. R. andHuizenga, K. A. Enzymatic Hydrolysis of L-Leucylglycine in Serum of Hepatic Disease.Proc. Staff Mayo Clinic 32:410–424, 1957.

  11. 11.

    Annotation-Leucine Amino-Peptidase.Brit. Med. J., Dec. 20, 1958. No. 5111, P. 1523.

  12. 12.

    Shay, H., andSiplet, H. The Value of Serum Alkaline Phosphatase, Determination and Bromsulphein Test in Diagnosis of Metastastic Cancer of the Liver.J. Lab. & Clin. Med. 43:741–751, 1954.

  13. 13.

    Althausen, T. L., andUyeyama, K. New Test of Pancreatic Function Based on Starch Tolerance.Ann. Int. Med., 41:563–575 (Sept.), 1954.

  14. 14.

    Sun, D. C. H. andShay, H. Value of Combined Study of Serum Enzymes and Duodenal Contents After Secretin in Diagnosis of Diseases of the Pancreas.Gastroenterology 32:212–231, 1957.

  15. 15.

    Sun, D. C. H. andShay, H. Pancreozymin-Secretin Test. Combined Study of Serum Enzymes and Duodenal Contents in Diagnosis of Pancreatic Disease. In Press.

  16. 16.

    Fleischer, G. A., Butt, H. R. andHuizenga, K. A. Serum Peptidases in Hepatic Disease.Ann. N. Y. Acad. Sci. 75:363–372, 1958.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Shay, H., Sun, D.C.H. & Siplet, H. Leucine aminopeptidase. Digest Dis Sci 5, 217–232 (1960). https://doi.org/10.1007/BF02231092

Download citation


  • Public Health
  • Leucine
  • Leucine Aminopeptidase