Clinical Rheumatology

, Volume 13, Issue 1, pp 90–97

Basement membrane proteins in synovial membrane: Distribution in rheumatoid arthritis and synthesis by fibroblast-like cells

  • M. Schneider
  • B. Voss
  • J. Rauterberg
  • M. Menke
  • Th. Pauly
  • R. K. Miehlke
  • J. Friemann
  • U. Gerlach


Rheumatoid arthritis is a complex disease of unknown origin. In consequence of some immunological reactions, proliferative invading synovial tissue leads to destruction of normal joint architecture. The aim of this study was to investigate qualitative changes in extracellular matrix distribution of proliferating rheumatoid synovium and their cellular origin. Synovial tissues from 57 clinically indicated arthrotomies were investigated with immunofluorescence, using specific antibodies against extracellular matrix proteins in tissue slides and cultured cells, which were also studied for collagen biosynthesis. Results indicated that synovial fibroblast-like cells synthesize and secrete basement membrane proteins laminin and collagen type IV as e.g. endothelial cells or organogenic fibroblasts. Laminin and collagen type IV were specifically demonstrated pericellularly in the hyperplastic lining layer of active rheumatoid synovitis. These findings are discussed with respect to the possible implication of altered cell-matrix interactions in rheumatoid synovial proliferation.

Key words

Rheumatoid Arthritis Synovium Extracellular Matrix Basement Membrane Proteins Immunohistochemistry 


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Copyright information

© Clinical Rheumatology 1994

Authors and Affiliations

  • M. Schneider
    • 1
  • B. Voss
    • 2
  • J. Rauterberg
    • 3
  • M. Menke
    • 1
  • Th. Pauly
    • 4
  • R. K. Miehlke
    • 5
  • J. Friemann
    • 6
  • U. Gerlach
    • 3
  1. 1.Medical Clinic and Policlinic BUniversity of MünsterGermany
  2. 2.Professional Associations' Research Institute for Occupational MedicineBochum
  3. 3.Institute for Arteriosclerosis ResearchMünster
  4. 4.Rhine Rheumatology Center MeerbuschGermany
  5. 5.Northwest German Center of Rheumatology SendenhorstGermany
  6. 6.Department of Environmental Pathology of the Institute for Environmental Hygiene at the University of DüsseldorfGermany
  7. 7.Center for Rheumatology, Medical Clinic and Policlinic BWestfalian Wilhelms-UniversityMünsterGermany

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