Clinical Rheumatology

, Volume 15, Issue 3, pp 254–260

Follow-up of 151 patients with high-titer U1RNP antibodies

  • P. B. Frandsen
  • N. J. Kriegbaum
  • S. Ullman
  • M. Høier-Madsen
  • A. Wiik
  • P. Halberg
Originals

DOI: 10.1007/BF02229703

Cite this article as:
Frandsen, P.B., Kriegbaum, N.J., Ullman, S. et al. Clin Rheumatol (1996) 15: 254. doi:10.1007/BF02229703

Summary

We performed a longitudinal follow-up study of clinical findings in 151 patients with high-titer antibodies against U1 ribonucleoprotein (U1RNP) as measured by haemagglutination. Formal connective tissue disease (CTD) diagnoses were assigned and diagnostic transitions analysed.

One-hundred eighteen females and 33 males entered the study; the mean duration of follow-up was 7.1 years. Mean age at entry was 34.7 years; 73% of the patients had early disease (duration <2 years). Fifty-six patients (37%) presented with a definite diagnosis, most often mixed connective tissue disease (MCTD, n=40), followed by systemic lupus erythematosus (SLE, n=11) and systemic sclerosis (SSc, n=5). Of 84 patients (56%) presenting with nonspecific symptoms of possible, “undifferentiated” CTD, 58 developed MCTD, 4 SSc and 2 SLE. By the end of the follow-up period, 127 patients had developed a well-defined CTD; final diagnoses were: MCTD (n=97), SLE (n=18), SSc (n=12).

We conclude that CTD in the context of high-titer anti-U1RNP antibodies may be transitive and sequential in nature, although the diagnostic criteria for MCTD previously proposed by our group seem to delimit a clinically stable condition in most patients in this subgroup.

Key words

Anti-U1RNP Antibodies Mixed Connective Tissue Disease 

Copyright information

© Clinical Rheumatology 1996

Authors and Affiliations

  • P. B. Frandsen
    • 1
  • N. J. Kriegbaum
    • 2
  • S. Ullman
    • 1
    • 3
  • M. Høier-Madsen
    • 1
    • 3
  • A. Wiik
    • 1
    • 5
  • P. Halberg
    • 1
    • 6
  1. 1.From the Department of NephrologyHvidovre University HospitalDenmark
  2. 2.Department of RheumatologyBispebjerg HospitalDenmark
  3. 3.Department of DermatologyRigshospitaletDenmark
  4. 4.Department of AutoimmunologyStatens SeruminstitutDenmark
  5. 5.Department of AutoimmunologyStatens SeruminstitutDenmark
  6. 6.Department of RheumatologyHvidovre University HospitalCopenhagenDenmark

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