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Associated polyneuropathy and demyelinating disease. Case report


We report a case in which an acute Guillain-Barré-like syndrome was quickly followed by a central demyelinating disease, documented by the clinical findings as well as by magnetic resonance imaging (MRI), electrophysiological and cerebrospinal fluid examinations. The close follow-on of the clinical signs seems to exclude a simple coincidence of two separate diseases and it may constitute further evidence for a possible etiological link between central and peripheral myelin damage. We discuss the possibility of a common pathogenic factor underlying central and peripheral demyelination.


Viene presentato un caso in cui ad una sindrome acuta tipo Guillain-Barré è successivamente seguita una malattia demielinizzante centrale, come documentato dal quadro clinico, dalla Risonanza Magnetica Nucleare (RMN), dalle indagini elettrofisiologiche e liquorali.

La particolare sequenza temporale della sintomatologia clinica sembra escludere una semplice coincidenza di due malattie distinte e sembra costituire una ulteriore prova di un possibile legame eziologico tra un danno mielinico centrale e periferico.

Viene discussa la possibilità che un comune fattore patogenetico possa essere responsabile di demielinizzazione centrale e periferica.

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Correspondence to Dr. W. Troni.

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Rebaudengo, N., Bianco, C., Ferrero, P. et al. Associated polyneuropathy and demyelinating disease. Case report. Ital J Neuro Sci 13, 793–796 (1992).

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Key Words

  • Polyneuropathy
  • demyelinating disease