The small number of adverse reactions to antimicrobial agents in the horse, recorded to date, reflects either a low level of reaction in the species or a failure to observe and report them, perhaps the latter. Reactions that have been observed could be due to toxic effects, e.g. discomfort after the intramuscular injection of chloramphenicol succinate; to hypersensitivity, e.g. the excitation or anaphylaxis observed after benzylpenicillins; and to biological or metabolic effects, e.g. changes in gut flora with oxytetracycline. A documentation of all reactions observed would both expand knowledge and protect horses known to have reacted.
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English, P.B., Roberts, M.C. Adverse reactions to antimicrobial agents in the horse. Vet Res Commun 7, 207–210 (1983). https://doi.org/10.1007/BF02228620
- Public Health
- Toxic Effect
- Adverse Reaction
- Antimicrobial Agent