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N-adamantyl derivatives of arylamides of α-azacycloalkanecarboxylic acids and their topical anesthetic activity

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Abstract

A series of arylamides of α-[N-adamantylpyrrolidyl-(or piperidyl)]carboxylic acids was obtained by reacting 1-(or 2-)aminoadamantanes with arylamides of α,Ω-dihalovaleric (or caproic) acid. The compounds exhibited a pronounced anesthetic activity in experiments.

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Avdyunina, N.I., Klimova, N.V., Lebedeva, A.S. et al. N-adamantyl derivatives of arylamides of α-azacycloalkanecarboxylic acids and their topical anesthetic activity. Pharm Chem J 29, 115–118 (1995). https://doi.org/10.1007/BF02226522

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Keywords

  • Organic Chemistry
  • Carboxylic Acid
  • Topical Anesthetic Activity
  • Anesthetic Activity
  • Piperidyl