Synthesis and antitumor properties of 13-dihydro-14-hydroxycarminomycin
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Reduction of the carbonyl group C(13) in 14-hydroxycarminomycin by the action of potassium borohydride yielded 13-dihydro-14-hydroxycarminomycin. Its antitumor activity was studied in comparison with carminomycin and doxorubicin for four tumors grafted to mice, namely, lymphadenosis HK/Li, ascitic Ehrlich carcinoma, hemocytoblastosis La, and leucemia P-388. The new compound was shown to have a high antitumor activity and a broad spectrum of antitumor action which is more pronounced than that of carminomycin and doxorubicin, while with respect to hemocytoblastosis La it is equal to the latter. Its effect on leukemia P-388 is lower than that of carminomycin. The drug exhibits considerable selectivity in its antitumor effect with respect to lymphadenosis HK/Li, exceeding the selectivity of doxorubicin and carminomycin. The selectivity of the antitumor effect of the drug with respect to Ehrlich carcinoma is virtually the same as that of carminomycin, but lower than that of doxorubicin.
KeywordsCarcinoma Potassium Leukemia Organic Chemistry Carbonyl
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