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Active sensitization does not increase the responsivity of rat peritoneal mast cells to diverse chemical stimuli

Abstract

Peritoneal mast cells from specific pathogen-free rats that had been sensitized to the nematodeNippostrongylus brasiliensis released histamine in a dose-dependent fashion on challenge with antigen, anti-rat IgE, anti-rat IgG and concanavalin A. Cells from non-sensitized animals showed weak or insignificant responses to these agents. However, the two preparations did not obviously differ in their reactivity to a range of pharmacological agents including ATP, dextran, polyamines and calcium ionophores. Both populations were refractory to cholinergic stimulation. These results show that active sensitization does notper se lead to a global increase in mast cell reactivity or releasability.

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Correspondence to P. T. Peachell.

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Peachell, P.T., Pearce, F.L. Active sensitization does not increase the responsivity of rat peritoneal mast cells to diverse chemical stimuli. Agents and Actions 27, 62–64 (1989). https://doi.org/10.1007/BF02222199

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Keywords

  • Mast Cell
  • Histamine
  • Dextran
  • Cell Reactivity
  • Concanavalin