Predictors of response to monoamine oxidase inhibitors: Do they exist?
- 31 Downloads
Multiple regression analysis was conducted on potential response predictors in a double-blind study of monoamine oxidase inhibitors (MAOI) and placebo treatment in 130 depressed outpatients. Positive main effects were found for sex (female), lack of prior hospitalization, presence of precipitating events. A negative main effect was found for concurrent physical illness. Treatment x predictor effects were found for distinct quality and non-reactivity. Non-reactivity was associated with positive outcome in both study groups, but the effect was significantly enhanced in the treatment group. Distinct quality demonstrated a more complex effect, its presence being associated with decreased improvement in the treatment group and greater improvement in the control group. No atypical depressive symptoms predicted MAOI response, and we were unable to characterize a specifically responsive MAOI syndrome.
Key wordsMAO inhibitors Response Predictors
Unable to display preview. Download preview PDF.
- Bhat AV, Rowan PRR, Paykel ES (1984) Responses to phenelzine and amitriptyline; absence of differential predictors by multiple regression analysis. J Affective Disord 6:209–218Google Scholar
- Carroll BJ (1984) Problems with diagnostic criteria for depression. J Clin Psychiatry 45 (7/2):14–18Google Scholar
- Davidson JRT, Turnbull CD (1984) The importance of dose in isocarboxazid therapy. J Clin Psychiatry 45 (7/2):49–52Google Scholar
- Feinberg M, Carroll BJ (1982) Separation of subtypes of depression using discriminate analysis: I. Separation of unipolar endogenous depression from non-endogenous depression. Br J Psychiatry 121:162–166Google Scholar
- Gurney C, Roth M, Garside RF, Kerr TA, Shapiro K (1972) Studies in the classification of affective disorders: The relationship between anxiety states and depressive illness. II. Br J Psychiatry 112:309–319Google Scholar
- Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychiatry 6:278–296Google Scholar
- Kraemer HC, Thiemann S (1987) How many subjects? Statistical power analysis in research. Sage, Newbury Park, CaliforniaGoogle Scholar
- Nolen WA (1986) Tranylcypromine in depression resistant to cyclic antidepressants. Clin Neuropharmacology 9 (Suppl 4):569–571Google Scholar
- Overall JE (1974) The Brief Psychiatric Rating Scale in psychopharmacological research. Modern Problems in Pharmacopsychiatry 7:67–78Google Scholar
- Pare CMB (1985) The present status of monoamine oxidase inhibitors. Br J Psychiatry 146:76–584Google Scholar
- Quitkin FM, Rifkin A, Klein DF (1979) Monoamine oxidase inhibitors. Arch Gen Psychiatry 35:749–760Google Scholar
- Quitkin FM, Stewart JW, McGrath PJ, Liebowitz MR, Harrison WM, Tricamo E, Klein DF, Rabkin JG, Markowitz JS, Wager SG (1988) Phenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders. Am J Psychiatry 145:306–311PubMedGoogle Scholar
- Raft D, Davidson JRT, Mattox A, Wasik J (1979) Double-blind evaluation of phenelzine, amitriptyline, and placebo in depression associated with pain. In: Singer A, von Korff RW, Murphy DL (eds) Monoamine Oxidase: Structure, Function and Altered Functions. Academic Press, New York, pp 507–516Google Scholar
- Zisook S, Braff DL, Click MA (1985) Monoamine oxidase inhibitors in the treatment of atypical depression. J Psychopharmacol 5:131–137Google Scholar