Predictors of response to monoamine oxidase inhibitors: Do they exist?

  • Jonathan R. T. Davidson
  • Earl L. Giller
  • Sidney Zisook
  • Michael J. Helms
Original Articles


Multiple regression analysis was conducted on potential response predictors in a double-blind study of monoamine oxidase inhibitors (MAOI) and placebo treatment in 130 depressed outpatients. Positive main effects were found for sex (female), lack of prior hospitalization, presence of precipitating events. A negative main effect was found for concurrent physical illness. Treatment x predictor effects were found for distinct quality and non-reactivity. Non-reactivity was associated with positive outcome in both study groups, but the effect was significantly enhanced in the treatment group. Distinct quality demonstrated a more complex effect, its presence being associated with decreased improvement in the treatment group and greater improvement in the control group. No atypical depressive symptoms predicted MAOI response, and we were unable to characterize a specifically responsive MAOI syndrome.

Key words

MAO inhibitors Response Predictors 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Jonathan R. T. Davidson
    • 1
  • Earl L. Giller
    • 2
  • Sidney Zisook
    • 3
  • Michael J. Helms
    • 4
  1. 1.Duke University Medical CenterDurhamUSA
  2. 2.Department of PsychiatryUniversity of Connecticut, School of MedicineFarmingtonUSA
  3. 3.University of California at San DiegoSan DiegoUSA
  4. 4.Biometry and Medicine Informations Division, C & F MedicineDuke University Medical CenterDurhamUSA

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