Avoidance behaviour: A predictor of the efficacy of pharmacotherapy in panic disorder?

  • Wolfgang Maier
  • Martin Roth
  • Nicholas Argyle
  • Raimund Buller
  • Philip Lavori
  • Sydney Brandon
  • Otto Benkert
Original Articles

DOI: 10.1007/BF02219714

Cite this article as:
Maier, W., Roth, M., Argyle, N. et al. Eur Arch Psychiatry Clin Nuerosci (1991) 241: 151. doi:10.1007/BF02219714

Summary

The impact of the avoidance behaviour on the psychopharmacological treatment of panic disorder was explored in the Cross National Collaborative Panic Study (n=1134 patients); in this double blind randomized trial alprazolam, imipramine and placebo were compared during an 8-week treatment period. Patients with extensive avoidance behaviour (agoraphobia) had the most profit from the active drugs. Counter expectancy these specific drug effects were most pronounced in avoidance behaviour. Active drugs (in particular imipramine) were especially more effective than placebo if the patients presented with associated avoidance behaviour. The results suggest that agoraphobia defines more a particular type of anxiety disorder overlapping with panic disorder than merely a severe state of panic disorder.

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Wolfgang Maier
    • 1
  • Martin Roth
    • 2
  • Nicholas Argyle
    • 3
  • Raimund Buller
    • 1
  • Philip Lavori
    • 4
  • Sydney Brandon
    • 5
  • Otto Benkert
    • 1
  1. 1.Department of PsychiatryUniversity of MainzMainzFederal Republic of Germany
  2. 2.Addenbrooke's HospitalUniversity of Cambridge Clinical School, Level 5CambridgeEngland
  3. 3.Westchester DivisionAnxiety and Depression Clinic, New York HospitalWhite PlainsUSA
  4. 4.Dept. of PsychiatryBrown UniversityProvidenceUSA
  5. 5.Leicester Royal InfirmaryLeicester UniversityLeicesterEngland

Personalised recommendations