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Pharmaceutisch Weekblad

, Volume 10, Issue 6, pp 284–286 | Cite as

Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration

  • G. E. C. J. M. van Oss
  • T. B. Vree
  • A. M. Baars
  • E. F. S. Termond
  • L. H. D. J. Booij
Short Communications

Abstract

Articainic acid, a major metabolite of articaine, was administered to a volunteer. Since the renewed interest in the utilization of articaine in epidural anaesthesia, it has been important to assess the clinical effects of this metabolite. It was noted that articainic acid had no effect on EEG, ECG, blood pressure and heart rate. Pharmacokinetic parameters are given.

Keywords

Articainic acid Drug evaluation Pharmacokinetics Pharmacology 

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References

  1. 1.
    Kaukinen L, Kaukinen S, Kärkkäinen S. Epidural-anästhesie mit Carticain bei Sectio Caesarea. Reg Anaesth 1986;9:79–83.PubMedGoogle Scholar
  2. 2.
    Vree TB, Baars AM, Van Oss GECJM, Booij LHDJ. High performance liquid chromatography and preliminary pharmacokinetics of articaine and its 2-carboxy metabolite in serum and urine of man. J Chromatogr 1988;424:440–4.PubMedGoogle Scholar
  3. 3.
    Jaffé M. Untersuchungen über die Entstehung des Kreatins im Organismus. Hoppe Seylers Z Physiol Chem 1906;48:430–68.Google Scholar
  4. 4.
    Metzler CM, Elfring GL, McEwen AJ. A package of computer programs for pharmacokinetic monitoring. Biometrics 1974;30:572–80.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1988

Authors and Affiliations

  • G. E. C. J. M. van Oss
    • 1
  • T. B. Vree
    • 2
    • 3
  • A. M. Baars
    • 2
  • E. F. S. Termond
    • 2
  • L. H. D. J. Booij
    • 4
  1. 1.Department of AnaesthesiologyHervormd DiaconessenhuisHK Arnhemthe Netherlands
  2. 2.Department of Clinical PharmacySint Radboud HospitalHB Nijmegenthe Netherlands
  3. 3.Department of AnaesthesiologySint Radboud HospitalNijmegen
  4. 4.Department of AnaesthesiologyFree University HospitalHV Amsterdamthe Netherlands

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