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The value of exogenous interferon in adenovirus keratoconjunctivitis

Preliminary results

Abstract

Fourteen patients with confirmed adenovirus (kerato-)conjunctivitis were treated at random with either exogenous interferon alpha (Le) (3 × 106 IU/ml, 1 drop daily) or with albumin. We observed no clinically relevant therapeutic effects. However, interferon seemed to exert a prophylactic effect on uninflamed fellow eyes. The prophylactic potency of interferon in adenovirus (kerato-)conjunctivitis should be evaluated in further controlled trials.

Zusammenfassung

Vierzehn Patienten mit gesicherter Adenovirus (Kerato-)Konjunktivitis wurden randomisiert entweder mit exogenem Interferon alpha (Le) (3 × 106 Einheiten/ml, 1 Tropfen täglich) oder mit Albumin-Tropfen behandelt. Klinisch relevante Therapieeffekte wurden nicht beobachtet. Das Interferon schien aber die noch nicht erkrankten Partneraugen vor der Erkrankung zu schützen. Diese prophylaktische Potenz des Interferons sollte weiter untersucht werden.

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Aided by a grant from the Bundesministerium für Jugend, Familie und Gesundheit

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Sundmacher, R., Wigand, R. & Cantell, K. The value of exogenous interferon in adenovirus keratoconjunctivitis. Graefe's Arch Clin Exp Ophthalmol 218, 139–140 (1982). https://doi.org/10.1007/BF02215650

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Keywords

  • Public Health
  • Albumin
  • Interferon
  • Therapeutic Effect
  • Conjunctivitis