Veterinary Research Communications

, Volume 8, Issue 1, pp 55–59

Adverse effects of imidocarb dipropionate (Imizol®) in a dog

  • A. Salam Abdullah
  • A. R. Sheikh-Omar
  • J. Desmond Baggot
  • M. Zamri
Article

Abstract

One of 13 healthy dogs used in a pharmacokinetic study of imidocarb dipropionate died due to difficulty in breathing, tachycardia, weakness and profuse diarrhoea. Autopsy findings showed marked pulmonary congestion and oedema. Kidneys were grossly enlarged and markedly congested with extensive haemorrhage in the cortex and medulla. Marked tubulonephrosis was also exhibited microscopically. Liver and spleen were moderately enlarged and congested. The adverse effects of imidocarb may be due to excessive acetylcholine action.

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Copyright information

© Elsevier Science Publishers B.V. 1984

Authors and Affiliations

  • A. Salam Abdullah
    • 1
  • A. R. Sheikh-Omar
    • 1
  • J. Desmond Baggot
    • 2
  • M. Zamri
    • 1
  1. 1.Faculty of Veterinary Medicine and Animal ScienceUniversiti Pertanian MalaysiaSelangorMalaysia
  2. 2.School of Veterinary MedicineUniversity of CaliforniaDavisU.S.A.

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