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Journal of Autism and Developmental Disorders

, Volume 18, Issue 4, pp 593–600 | Cite as

Correlation of family history with specific autistic subgroups: Asperger's syndrome and bipolar affective disease

  • G. Robert DeLong
  • Judith T. Dwyer
Article

Abstract

The etiology of infantile autism is not known. To assess the possible role of familial psychopathology, we investigated a group of autistic subjects subgrouped by level of language functin. Family histories were obtained by the family history method. Neurological status was assessed by neurological diagnostic examination and prenatal and perinatal history. The results showed a high incidence of Asperger's syndrome in family members of high-functioning autistic subjects only. The rate of bipolar affective disorder in family members was 4.2%, higher than in the general population; it was significantly higher in families with Asperger's syndrome, suggesting an etiological link between Asperger's syndrome and manic depression. Positive neurological findings were concentrated in the low-functioning subgroup. These findings imply different etiologies for high- versus low-functioning autism, with high-functioning autism related to familial factors, especially Asperger's syndrome.

Keywords

Family History Manic Depression Affective Disorder Neurological Finding Bipolar Affective Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, DC: Author.Google Scholar
  2. Andreason, N. C., Endicott, T. J., Spitzer, R. C., et al. (1977). The family history method using diagnostic criteria.Archives of General Psychiatry, 34, 1229–1235.Google Scholar
  3. DeLong, G. R., & Aldershof, A. L. (1983). Asoociation of special abilities with juvenile manic-depressive illness.Annals of Neurology, 14, 362.Google Scholar
  4. Dwyer, J., & DeLong, G. R. (1987). A family history study of 20 probands with childhood manic-depressive illness.Journal of the American Academy of Child Psychiatry, 26, 176–180.Google Scholar
  5. Eisenberg, L. (1956). The autistic child in adolescence.American Journal of Psychiatry, 112, 607–612.Google Scholar
  6. Gillberg, C. (1985). Asperger's syndrome and recurrent psychosis — a case study.Journal of Autism and Developmental Disorders, 15, 389–397.Google Scholar
  7. Herzberg, B. (1976). The families of autistic children. In M. Boleman (Ed.),The autistic syndromes (pp. 151–172). Amsterdam: North Holland.Google Scholar
  8. Hollingshead, A. (1975).Four-factor index of social status. Privately published (Available from Department of Sociology, Yale Universiy, PO Box 1965, New Haven, CT 06520.)Google Scholar
  9. Klerman, G. (1981). Overview of affective disorder. In Freedman & Kaplan (Eds.),Comprehensive textbook of psychiatry (Vol. 20, pp. 1305–1319). Baltimore: Williams and Wilkins.Google Scholar
  10. Komoto, J., Usui, S., & Hiratu, J. (1984). Infantile autism and affective disorder.Journal of Autism and Developmental Disorders, 14, 81–84.Google Scholar
  11. Robins, L. N., Helzer, J. E., Weissman, M. M., Orvaschel, H., Gruenberg, E., Burke, J. D., & Regier, D. A. (1984). Lifetime prevalence of specific psychiatric disorders in three sites.Archives of General Psychiatry, 41, 949–958.Google Scholar
  12. Ruter, M. (1983). Cognitive deficits in the pathogenesis of autism,Journal of Child Psychology and Psychiatry, 24, 513–531.Google Scholar
  13. Szatmari, P. (1986, October).Asperger's syndrome and autism: Differences and diagnostic validity. Paper presented at the symposium on non-autistic pervasive developmental disorders at the annual meetng of the American Academy of Child Psychiatry, Los Angeles.Google Scholar
  14. Wing, L. (1981). Asperger's syndrome: A clinical account.Psychological Medicine, 11, 115–129.Google Scholar
  15. Wing, L., & Gould, J. (1979). Severe impairments of social interaction and associated abnormalities in children; epidemiology and classification.Journal of Autism and Developmental Disorders, 9, 11–29.Google Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • G. Robert DeLong
    • 1
  • Judith T. Dwyer
    • 2
  1. 1.Division of Pediatric NeurologyDuke UniversityMedical CenterUSA
  2. 2.Department of NeurologyTufts New England Medical CenterUSA

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