Journal of Assisted Reproduction and Genetics

, Volume 12, Issue 2, pp 106–112 | Cite as

Increased incidence of aberrant morphological phenotypes in human embryogenesis—An association with endometriosis

  • Cathy L. Brizek
  • Sheldon Schlaff
  • Vincent A. Pellegrini
  • Jeffrey B. Frank
  • Kathryn C. Worrilow
Clinical Assisted Reproduction



After noticing specific aberrant forms of development in preimplantation embryos from women with endometriosis, we embarked upon this study in order to examine the frequency of these events as compared with controls.


A total of 235 embryos representing 30 women undergoing 56 cycles of in vitrofertilization were retrospectively analyzed on videotape and placed into categories based upon the incidence of specific morphological criteria found during observations made on the first and second days following oocyte retrieval.


Several of the aberrant nuclear and cytoplasmic events were found to be statistically increased in the group of embryos from women with endometriosis.


The incidence of defined aberrant phenotypes in embryos from women with laparoscopically documented endometriosis may allow us to identify specific embryotoxic events with reference to endometriosis and other diagnoses.

Key words

in vitro fertilization embryogenesis endometriosis embryo morphology 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Cathy L. Brizek
    • 1
  • Sheldon Schlaff
    • 1
    • 2
  • Vincent A. Pellegrini
    • 1
  • Jeffrey B. Frank
    • 1
  • Kathryn C. Worrilow
    • 1
    • 3
  1. 1.Women's Clinic, Ltd./Fertility Medical Labs Ltd.Reading Hospital and Medical CenterWest Reading
  2. 2.Pennsylvania Endocrine LaboratoryPennsylvania HospitalPhiladelphia
  3. 3.Department of Obstetrics and GynecologyAlbert Einstein Medical CenterPhiladelphia

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