Digestive Diseases and Sciences

, Volume 41, Issue 1, pp 180–184 | Cite as

Nafcillin-associated hepatotoxicity

Report of a case and review of the literature
  • Michael E. Presti
  • Christine G. Janney
  • Brent A. Neuschwander-Tetri
Liver: Infectious, Inflammatory, and Metabolic Disorders Case Report


Nafcillin is a semisynthetic penicillin that is generally well tolerated with few side effects. Hepatic complications are rare but have a potential for serious liver dysfunction. This unusual complication causes a predominantly cholestatic injury, which can persist for prolonged periods even after discontinuing the medication. The pathophysiology may include direct cytotoxicity or an immune-mediate hypersensitivity. Treatment is generally supportive, except for severely symptomatic patients who may require steroids. We report a case of nafcillin-associated hepatotoxicity and review the literature of this disorder.

Key Words

nafcillin cholestasis liver diseases hepatotoxicity 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Michael E. Presti
    • 1
    • 2
  • Christine G. Janney
    • 1
    • 2
  • Brent A. Neuschwander-Tetri
    • 1
    • 2
  1. 1.Division of Gastroenterology and HepatologySaint Louis University Health Sciences Centersaint Louis
  2. 2.Department of PathologySaint Louis University Health Sciences Centersaint Louis

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