Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Spinal abnormalities similar to ankylosing spondylitis in a 58-year-old woman with ochronosis

  • 24 Accesses

  • 15 Citations


Ochronotic arthropathy (spondylosis or peripheral arthropathy) is a late complication of alkaptonuria. There is a tendency for HLA-B27 positive patients with alkaptonuria to develop ochronotic spondylosis. A 58-year-old white woman, presented with ochronotic spondylosis. She was HLA-B27 positive. Her family history was positive for alkaptonuria. Ochronotic patients with HLA-B27 positivity develop spinal changes similar to ankylosing spondilitis (AS).

This is a preview of subscription content, log in to check access.


  1. 1.

    Snick, D. Alkaptonuria. In: Diagnosis of Bone and Joint Disorders. Eds.: Resnick, D., Niwayama, G. Philadelphia, WB Saunders, 1988, 787–1803.

  2. 2.

    Wyngaarden, J.B. Alkaptonuria. In: Cecil Textbook of Medicine. Eds.: Beeson, P.B.N., McDermott, W., Wyngaarden, J.B., 15th ed. Philadelphia, WB Saunders Co, 1979, 2026.

  3. 3.

    Gemignani, G., Olivieri, I., Semeria, R., Giustarini, S., Pasero, G., Coexistence of ochronosis and ankylosing spondylitis. J Rheumatol 1990, 17, 1707–1709.

  4. 4.

    Keyser, F.D., Paepe, A.D., Veys, E.M. (Letter to editors) Ochronotic arthropathy and ankylosing spondylitis in an HLA-B27 positive patient. J Orthopaedic Rheumatol 1990, 3, 119.

  5. 5.

    Weinberger, K.A. Coexistence of ochronosis and ankylosing spondylitis. J. Rheumatol 1991, 18, 1264–1265.

  6. 6.

    Yagan, R., Khan, M.A. Coexistence of ochronosis and ankylosing spondylitis. J Rheumatol 1991, 18, 1639.

  7. 7.

    Gemignani, G., Olivieri, I., Pasero, G. Coexistence of ochronosis and ankylosing spondylitis (Reply). J Rheumatol 1991, 18, 1639–1640.

  8. 8.

    O'Brian, W.M., Ladu, B.N., Bumin, J.J. Biochemical, pathologic and clinical aspects of alkaptonuria, ochronosis and ochronotic arthropathy. Am J Med 1963, 34, 813–814.

  9. 9.

    Silverman, L.M., Christenson, R.H. Aminoacids and proteins. In: Textbook of Clinical Chemistry. Ed.: Tietz, N.W., W.B. Saunders Co., 1986, 554.

  10. 10.

    Yenson, M. Klinik Biyokimya Laboratuvar Calismalari (in Turkish). Istanbul Universitesi Tip Fakültesi. Rektörlük No: 2950, Fakülte No: 139 Sanat Matbaacilik 1982, 169. Eds.: Peyman, Sanders, Goldberg, Philadelphia, 1980, 1750.

  11. 11.

    Smith, R.E., Lee, J.S. The cornea in systemic disease. In: Clinical Ophthal, Ed.: Duane, D.T. New York, 1985, 4–5.11.

  12. 12.

    Cross, H.E. Genetics and eye disease. In: Principles and Practive of Ophthalmology, Eds.: Peyman, Sanders, Goldberg, Philadelphia 1980, 1750.

  13. 13.

    Zanetakis, E., Khan, M.A., Yagan, R., Kushner, I. Ochronotic arthropathy, post traumatic spinal pseudoarthrosis and HLA-B27. J Orthopaedic Rheumatol 1989, 2, 48–53.

  14. 14.

    Gaucher, A., Pourel, J., Raffoux, C., Faure, G., Netter, P., Streiff, F. HLA antigens and alkaptonuria. J Rheumatol 1977, (Suppl.3) 4, 97–100.

  15. 15.

    Müftüoglu, A., Yazici, H., Yurdakul, S. Behçet's disease: lack of correlation of clinical manifestation with HLA antigen. Tissue Antigen 1981, 17, 212–230.

  16. 16.

    Dilsen, N., Koniçe, M., Oral, A. Behçet's disease should be accepted as a seronegative arthritis. In: Recent advances in Behçet's disease. International Congress and Symposium Series. Eds.: Lener, T., Barnes, C.G.. Number 103, Royal Society of Medicine Service, London 1986, 281–284.

  17. 17.

    Brewerton, D.A., Caffrey, M., Nicholls, A. Ankylosing spondylitis and HLA-27. Lancet 1973, i, 904–907.

Download references

Author information

Correspondence to Dr. Y. Kabasakal.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kabasakal, Y., Kiyici, I., Özmen, D. et al. Spinal abnormalities similar to ankylosing spondylitis in a 58-year-old woman with ochronosis. Clin Rheumatol 14, 355–357 (1995). https://doi.org/10.1007/BF02208354

Download citation

Key words

  • Ochronosis
  • Spondylosis
  • Ochronotic Arthropathy