Clinical Rheumatology

, Volume 10, Issue 2, pp 211–214 | Cite as

Histopathological findings in a case of systemic lupus erythematosus-associated anti-phospholipid syndrome

  • P. L. Meroni
  • R. Rivolta
  • P. Ghidoni
Case Report


The vessel anatomopathological lesions in a patient with systemic lupus erythematosus associated anti-phospholipid syndrome are described. Vasculitic lesions were nearly absent but small vessels showed hyalin thrombosis or substenosis due to subendothelial deposition of amorphous PAS-positive material in different anatomical districts. These findings can be related to the patient's clinical manifestations, particularly the central nervous system involvement and can be discussed regarding the possible pathogenetic mechanisms.

Key words

Anti-Phospholipid Syndrome Systemic Lupus Erythematosus Thrombosis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hughes, G.R.V. Thrombosis, abortion, cerebral disease and the lupus anticoagulant. Br Med J 1983, 287, 1088–1089.Google Scholar
  2. 2.
    Shapiro, S.S., Thiagarajan, P. Lupus anticoagulant. Prog Haemostas Thromb 1982, 6, 263–285.Google Scholar
  3. 3.
    Derksen, R.H.W.M., Kater, L. Lupus anticoagulant revival of an old phenomenon. Clin Exp Rheumatol 1985, 3, 349–353.Google Scholar
  4. 4.
    Asherson, R.A., Khamashta, M.A., Gil, A., Vazquez, J.J., Chan, O., Baguley, E., Hughes, G.R.V. Cerebrovascular disease and anti-phospholipid antibodies in systemic lupus erythematosus, lupus-like disease and the primary anti-phospholipid syndrome. Am J Med 1989, 86, 391–399.Google Scholar
  5. 5.
    Harris, E.N., Gharavi, A.E., Hughes, G.R.V. Anti-phospholipid antibodies. Clin Rheus Dis 1985, 11, 591–609.Google Scholar
  6. 6.
    Alarcon-Segovia, D., Cardiel, M.H., Reyes, E. Anti-phospholipid arterial vasculopathy. J Rheumatol 1989, 16, 762–767.Google Scholar
  7. 7.
    Harris, E.N., Gharavi, A.E., Patel, S.P., Hughes, G.R.V. Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4th April 1986. Clin Exp Immunol 1987, 68, 215–222.Google Scholar
  8. 8.
    Meroni, P.L., Harris, E.N., Brucato, A., et al. Anti-mitochondrial type M5 and anti-cardiolipin antibodies in autoimmune disorders: studies on their association and cross-reactivity. Clin Exp Immunol 1987, 67, 484–491.Google Scholar
  9. 9.
    Derue, G., Englert, H.J., Harris, E.N. et al. Fetal loss in systemic lupus erythematosus: association with anti-cardiolipin antibodies. J Obstet Gynaecol 1985, 5, 207–209.Google Scholar
  10. 10.
    Lockshin, M.D., Druzin, M.L., Goei, S. et al. Antibody to cardilipin as a predictor of fetal distress or death in pregnant patient with systemic lupus erythematosus. N Engl J Med 1985, 313, 152–156.Google Scholar
  11. 11.
    Branch, D.W., Scott, J.R., Kochenour, N.K., Hershgold, E. Obstetric complications associated with the lupus anticoagulant. N Engl J Med 1985, 313, 1322–1326.Google Scholar
  12. 12.
    Khamashta, M.A., Cervera, R., Asherson, R.A. et al. Association of antibodies against phospholipids with heart valve disease in systemic lupus erythematosus. Lancet 1990, 335, 1541–1544.Google Scholar
  13. 13.
    Levine, S.R., Welch, K.M.A. The spectrum of neurologic disease: association with anti-phospholipid antibodies. Arch Neurol 1987, 44, 877–883.Google Scholar
  14. 14.
    Coull, B.M., Bourdette, D.N., Godnight, S.H., et al. Multiple cerebral infarctions and dementia associated with anti-cardiolipin antibodies. Stroke 1987, 18, 1107–1112.Google Scholar
  15. 15.
    Asherson, R.A., Derksen, R.H.W.N., Bouma, B.N. et al. Chorea in systemic lupus erythematosus and “lupus-like” disease: association with anti-phospholipid antibodies. Semin Arthritis Rheum 1987, 16, 253–259.Google Scholar
  16. 16.
    Alarcon-Segovia, D. Pathogenetic potential of anti-phospholipid antibodies. J Rheumatol 1988, 15, 890–893.Google Scholar
  17. 17.
    Tincani, A., Meroni, P.L., Valesini, G. et al. Immunological studies with ACA: reactions with cells. Proceed. of the ILAR'89 Congress — Rio de Janeiro — September 1989, pp. 39–41.Google Scholar
  18. 18.
    Johnson, R.T., Richardson, E.P. The neurological manifestations of systemic lupus erythematosus: a clinical study of 24 cases snd review of the literature. Medicine 1968, 47, 337–369.Google Scholar
  19. 19.
    Ellis, S.G., Verity, M.A. Central nervous system involvement in systemic lupus erythematosus: a review of neuropathologic findings in 57 cases, 1955–1977. Semin Arthritis Rheum 1979, 8, 212–221.Google Scholar
  20. 20.
    Graham, E.M., Spalton, D.J., Barnard, R.O., Garner, A., Ross Russell, R.W. Cerebral and renal vascular changes in systemic lupus erythematosus. Ophthalmology 1985, 92, 444–448.Google Scholar
  21. 21.
    Vismara, A., Meroni, P.L., Tincani, A., et al. Relationship between anticardiolipin and anti-endothelial cell antibodies in SLE. Clin Exp Immunol 1988, 74, 247–253.Google Scholar

Copyright information

© Acta Medica Belgica 1991

Authors and Affiliations

  • P. L. Meroni
    • 1
  • R. Rivolta
    • 1
  • P. Ghidoni
    • 2
  1. 1.Istituto di Medicina InternaMalattie infettive ImmunopathologiaItaly
  2. 2.Istituto di Anatomia PatologicaUniversity of MilanItaly

Personalised recommendations