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Antineutrophil cytoplasmic antibodies (ANCA) and vasculitis

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The demonstration of autoantibodies to different myeloid lysozomal enzymes has opened a new area for the study of vasculitic syndromes. Autoantibodies producing a granular cytoplasmic staining by IIF (c-ANCA, probably directed to a putative serine protease) are closely associated with Wegener's granulomatosis. Autoantibodies to myeloperoxydase (producing a perinuclear staining by IIF, p-ANCA) are associated with idiopathic crescentic glomerulonephritis and polyarteriitis nodosa/Churg Strauss syndrome. These strong associations suggest a pathophysiological role for the autoantibodies in the diseases with which they are associated.

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Kallenberg, C.G.M. Antineutrophil cytoplasmic antibodies (ANCA) and vasculitis. Clin Rheumatol 9, 132–135 (1990). https://doi.org/10.1007/BF02205561

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  • Public Health
  • Serine
  • Strong Association
  • Vasculitis
  • Serine Protease