Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Antineutrophil cytoplasmic antibodies (ANCA) and vasculitis

  • 19 Accesses

  • 12 Citations

Conclusion

The demonstration of autoantibodies to different myeloid lysozomal enzymes has opened a new area for the study of vasculitic syndromes. Autoantibodies producing a granular cytoplasmic staining by IIF (c-ANCA, probably directed to a putative serine protease) are closely associated with Wegener's granulomatosis. Autoantibodies to myeloperoxydase (producing a perinuclear staining by IIF, p-ANCA) are associated with idiopathic crescentic glomerulonephritis and polyarteriitis nodosa/Churg Strauss syndrome. These strong associations suggest a pathophysiological role for the autoantibodies in the diseases with which they are associated.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    van Wingerden, I., van der Giessen, M., The, T.H., Rümke, Ph. Demonstration of circulating immune complexes in melanoma patients by means of a granulocyte phagocytosis test. Protides Biol Fluids, Proceedings 1978, 26, 345–348.

  2. 2.

    van der Woude, F.J., Rasmussen, N., Lobatto, S., Wiik, A., Permin, H., van Es, L.A., van der Giessen, M., van der Hem, G.K. The, T.H. Autoanti- bodies to neutrophils and monocytes: a new tool for diagnosis and a marker of disease activity in Wegener's Granulomatosis. Lancet 1985, i, 425–429.

  3. 3.

    Lüdemann, G., Nölle, B., Rautmann, A., Rosenboom, S., Kekow, J., Gross, W.L. ACPA als Seromarker und AktivitÄtsparameter der Wegener'schen Granulomatose: Eine prospektive Studie. Dtsch Med Wochenschr 1988, 113, 413–417.

  4. 4.

    Cohen Tervaert, J.W., van der Woude, F.J., Fauci, A.S., Ambrus, J.L., Velosa, J., Keane, W.F., Meijer, S., van der Giessen, M. The, T.H. van der Hem, G.K., Kallenberg, C.G.M. Association between active Wegener's Granulomatosis and anti-cytoplasmic antibodies (ACPA). Arch Intern Med 1989, 149, 2461–2465.

  5. 5.

    Goldschmeding, R., ten Bokkel Huinink, D., Faber, N., Tetteroo, P.A.T., Vroom, T.M., Hack, C.E., von dem Borne, A.E.G. Kr. Identification of the ANCA-antigen as a novel myeloid lysozomal serine protease. APMIS 1989, 97, S6, 48.

  6. 6.

    Lockwood, C.M., Bakes, D., Jones, S., Whitaker, K.B., Moss, D.W., Savage, C.O.S. Association of alkaline phosphatase with an autoantigen recognized by circulating anti-neutrophil antibodies in systemic vasculitis. Lancet 1987, i, 716–720.

  7. 7.

    Goldschmeding, R., van der Schoot, C.E., van der Snoek, M.A., von dem Borne, A.E.G.Kr. A monoclonal antibody against the 29 KD ANCA-anti-gen: application as catching antibody in a sandwich-ELISA for ANCA detection. APMIS 1989, 97, S6, 47.

  8. 8.

    Goldschmeding, R., Cohen Tervaert, J.W., van der Schoot, C.E., van der Giessen, M., von dem Borne, A.E.G.Kr., Kallenberg, C.G.M. Autoantibodies against myeloid lysozomal enzymes: a novel class of autoantibodies associated with vasculitic syndromes. Kidney Int 1988, 34, 558.

  9. 9.

    Goldschmeding, R., Cohen Tervaert, J.W., van der Schoot, C.E., van der Veen, C., Kallenberg, C.G.M., von dem Borne, A.E.G.Kr. ANCA, anti-myeloperoxydase, and elastase: three members of a novel class of autoantibodies against myeloid lysozomal enzymes. APMIS 1989, 97, S6, 48–49.

  10. 10.

    Falk, R.J., Jennette, J.C. Anti-neutrophil cytoplasmic autoantibodies with specificity for myelop-eroxydase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988, 318, 1651–1657.

  11. 11.

    Cohen Tervaert, J.W., Goldschmeding, R., Elema, J.D., van der Hem, G.K., Kallenberg, C.G.M. Association of segmental crescentic glomerulonephritis with autoantibodies directed against different lysozomal enzymes. Kidney Int 1989, 35, 208.

  12. 12.

    Pinching, A.J., Rees, A.J., Pussell, B.A., Lockwood, C.M., Mitchison, P.S., Peters, D.K. Relapses in Wegener's granulomatosis: the role of infection. Br Med J 1980, 281, 836–838.

  13. 13.

    Weiss, S.J. Tissue destruction by neutrophils. N Engl J Med 1989, 320, 365–376.

  14. 14.

    Daha, M.R., van Es, L.A. Further evidence for the antibody nature of C3 nephritic factor (C3NeF). J Immunol 1979, 123, 755–758.

  15. 15.

    Davies, M., Barrett, A.J., Travis, J., Sanders, E., Coles, G.A. The degradation of human glomerular basement membrane with purified lysozomal proteinases: evidence for the pathogenic role of polymorphonuclear leucocyte in glomerulonephritis. Clin Sci Mol Med 1978, 54, 233–240.

  16. 16.

    Johnson, R.J., Guggenheim, S.J., Klebanoff, S.J., et al. Morphologic correlates of glomerular oxidant injury induced by the myeloperoxydase-hydrogen peroxide-halide system of the neutrophil. Lab Invest 1988, 58, 294–301.

  17. 17.

    Kallenberg, C.G.M., Goldschmeding, R., Cohen Tervaert, J.W., von dem Borne, A.E.G.Kr. Autoantibodies to myeloid enzymes: new clues to vasculitis and glomerulonephritis. Neth J Med 1990, in press.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kallenberg, C.G.M. Antineutrophil cytoplasmic antibodies (ANCA) and vasculitis. Clin Rheumatol 9, 132–135 (1990). https://doi.org/10.1007/BF02205561

Download citation

Keywords

  • Public Health
  • Serine
  • Strong Association
  • Vasculitis
  • Serine Protease