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, Volume 5, Issue 4, pp 322–325 | Cite as

Anti-inflammatory drugs and renal papillary necrosis

  • Edward H. Wiseman
  • Harald Reinert
Immunosuppression and Inflammation Mini-Review

Abstract

The literature on renal papillary necrosis (RPN) associated with the administration of non-steroidal antiinflammatory drugs (NSAID) to rats and man, is reviewed. RPN is almost universally reported after long term administration of NSAID to rats, reports being cited for an indomethacin analog, phenylbutazone, fenamic acids, fenoprofen and sudoxicam. Aspirin will also induce RPN in rats, and is probably the cause of the ‘analgesic nephropathy’ linked to abuse of aspirin/phenacetin combinations in man. RPN is reported at autopsy in human arthritics, but whether this is a facet of the disease, or of long term salicylate ingestion, is not clear. NSAID are rarely implicated in RPN in humans.

Keywords

Aspirin Indomethacin Salicylate Phenylbutazone Term Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser-Verlag 1975

Authors and Affiliations

  • Edward H. Wiseman
    • 1
    • 2
  • Harald Reinert
    • 1
    • 2
  1. 1.Department of PharmacologyPfizer Central ResearchGrotonUSA
  2. 2.Research CenterAmboiseFrance

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