Two different discrimination learning experiments, the first using rats and the second cats, provide clear support for facilitation of acquisition rate by physostigmine injections. The results suggest that facilitating effects of physostigmine may be limited to a small dose range (.025–.075 mg/kg), although such facilitatory effects may be limited to discrimination learning.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Bureš, J., Z. Bohdanecký, andT. Weiss: Physostigmine induced hippocampal theta activity and learning in rats. Psychopharmacologia (Berl.)3, 254–263 (1962).
Harlow, H. F.: The formation of learning sets. Psychol. Rev.56, 51–65 (1949).
McLennan, H.: Synaptic Transmission. Philadelphia: Saunders 1963.
Newby, N., and N. J.Carlson: The effects of dl-amphetamine and eserine on T-maze learning and reversal. Paper read at Midwestern Psychological Association Meetings. Chicago. May 1965.
Russell, R. W., R. H. J. Watson, andM. Frankenhaeuser: Effects of chronic reductions in brain cholinesterase activity on acquisition and extinction of a conditioned avoidance response. Scand. J. Psychol.2, 21–29 (1961).
Siegel, S.: Nonparametric Statistics for the Behavioral Sciences. New York: McGraw-Hill 1956.
Whitehouse, J. M.: Cholinergic mechanisms in discrimination learning with redundant cues. Paper read at Midwestern Psychological Association Meetings. Chicago: May 1965.
This investigation was supported by the United States Army Medical Research and Development Command, Department of the Army, under Research Contract No. DA-49-193-MD-2412.
About this article
Cite this article
Whitehouse, J.M. The effects of physostigmine on discrimination learning. Psychopharmacologia 9, 183–188 (1966). https://doi.org/10.1007/BF02198478
- Learning Experiment
- Dose Range
- Small Dose
- Facilitatory Effect
- Discrimination Learning