Plant Foods for Human Nutrition

, Volume 40, Issue 4, pp 275–282 | Cite as

Studies on the effect of curry leaves supplementation (Murraya koenigi) on lipid profile, glycated proteins and amino acids in non-insulin-dependent diabetic patients

  • U. M. Iyer
  • U. V. Mani


Curry leaves powder supplementation (12 g providing 2.5 g fibre) was carried out for a period of 1 month in 30 non-insulin dependent diabetes mellitus patients. The parameters monitored at 1, 15 and 30 days were fasting and 2 h post-prandial blood sugar levels, serum total cholesterol and its lipoprotein fractions, triglycerides, total amino acids, uronic acid, glycosylated serum proteins and glysocylated low density lipoprotein cholesterol fraction. The results indicated a transient reduction in fasting and post-prandial blood sugar levels at 15-day period with no appreciable changes in serum glycosylated protein levels, glycosylated low density lipoprotein cholesterol fraction, serum lipids, lipoprotein cholesterol levels, uronic acid and total amino acids were observed during the supplementation period, i.e. either at 15 days or 30 days.

Key words

diabetes mellitus curry leaves supplementation blood sugar glycosylated serum protein lipid profile total amino acid 


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  1. 1.
    World Health Organisation (1985) Diabetes Mellitus. Tech Rep Ser 727: 1–113Google Scholar
  2. 2.
    Mani I, Patel HR, Shah PB, Mani UV (1986) Influence of blood sugar and duration of the disease on serum lipids in maturity onset diabetic patients. Indian J Clin Biochem 1: 39–44Google Scholar
  3. 3.
    Mani I, Patel JJ, Mani UV (1987) Measurement of serum glycosylated protein and glycosylated low density lipoprotein fraction in the serum of diabetics. Biochem Med 37: 184–189Google Scholar
  4. 4.
    Jenkins DJA, Wolever TMS, Horwarth R, Leeds AR, Hockaday TDR (1976) Guar gum in diabetes. Lancet 2: 1086–1087Google Scholar
  5. 5.
    Jenkins DJA, Wolever TMS, Hockaday TDR, Leeds AR, Horwarth R, Bacon S, Abliny EC, Dilwari J (1977) Treatment of diabetes with guar gum. Reduction in urinary glucose levels in diabetes. Lancet 2: 779–780Google Scholar
  6. 6.
    Miranda PM, Horwitz DL (1978) High fibre diet in the treatment of diabetes mellitus. Ann Int Med 88: 482–486Google Scholar
  7. 7.
    Andersen JW, Chan WL (1979) Plant fibre carbohydrate and lipid metabolism. Am J. Clin Nutr 32: 346–363Google Scholar
  8. 8.
    Goswamy S, Mani I, Mani UV (1985) Effect of wheat bran on tissue lipids in diabetic rats. Ind J Biochem and Biophys 22: 140–143Google Scholar
  9. 9.
    Mani I, Patel JJ, Mani UV (1987) Effect of wheat bran supplementation on serum lipids and urinary imino acids in maturity onset diabetics. J Clin Biochem and Nutr 3: 143–148Google Scholar
  10. 10.
    Mani I, Mani UV (1987) Effect of wheat bran supplementation on blood sugar, glycosylated protein and serum lipids in NIDDM subjects. Plant Foods Hum Nutr 37: 161–168Google Scholar
  11. 11.
    Mani UV, Sharma M, Waghray K, Iyer UM, Mani I (1989) Effect of colocasia leaves (Colocasia antiquorum) on serum and tissue lipids in cholesterol-fed rats. Plant Foods Hum Nutr 39: 245–255Google Scholar
  12. 12.
    Gopalan C, Rama Sastri BV, Balasubramanian SC (1984) Nutritive Value of Indian Foods. National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, IndiaGoogle Scholar
  13. 13.
    CSIR Diagnostic Kit for Blood Sugar (1959) Method of Hultman E. Nature (London) 183: 108–109Google Scholar
  14. 14.
    Christopher K, Frings CS, Fendly TW, Dunn RT, Queen CA (1972) Improved determination of total serum lipids by the sulpho-phospho vanillin reaction. Clin Chem 18: 673–674Google Scholar
  15. 15.
    Foster LB, Dunn RJ (1973) Stable reagents for the determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin Chem 19: 338–346Google Scholar
  16. 16.
    Bitter T, Muir H (1962) Colorimetric determination of uronic acid. Annal Biochem 4: 330–335Google Scholar
  17. 17.
    Rosen H (1957) Modified ninhydrin colorimetric analysis for amino acids. Arch Biochem Biophys 67: 10–15Google Scholar
  18. 18.
    Ranbaxy diagnostic enzymatic kit for total cholesterol using CHOD-PAD method supplied by Ranbaxy Company, IndiaGoogle Scholar
  19. 19.
    Warnick GR, Mayfield CB, Benderson JBS, Chen JS, Albert JJ (1982) HDL-cholesterol quantification by phosphotungstate Mg+2 and by dextran sulfate M2 +2 polyethylene glycol precipitation. Both with the enzymic cholesterol assay compared with the lipid research method. Am J Clin Pathol 78: 718–722Google Scholar
  20. 20.
    Weiland H, Seidel D (1983) A simple specific method for precipitation of low density lipoprotein. J Lipid Res 24: 904–908Google Scholar
  21. 21.
    Vahouny GV (1982) Conclusions and recommendations of the symposium on dietary fibres in health and disease. Am J Clin Nutr 35: 152–156Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • U. M. Iyer
    • 1
  • U. V. Mani
    • 1
  1. 1.Department of Foods and NutritionMS University of BarodaBarodaIndia

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