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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 1570–1574 | Cite as

The influence of glutathione on the photoreaction of 3,4′,5-tribromosalicyl-anilide alone and in the presence of serum albumin

  • H. De Vries
  • G. M. J. Beijersbergen Van Henegouwen
Article

Abstract

Glutathione is known to play a prominent detoxifying role in the organism. In this study attention has been paid to the possible occurrence of a detoxifying action of glutathione in the skin. For this reason we studied the influence of glutathione on the photoreaction of 3,4′,5-tribromosalicylanilide (Tbsa), which is notorious for causing photoallergy. It was found thatTbsa forms stable photoconjugates on irradiation with glutathione: 3-glutathyl-4′,5-dibromosalicylanilide and 5-glutathyl-4′-bromosalicylanilide. The rate of the photoreaction ofTbsa in the presence of glutathione, resulting in photostable products, is increased. Furthermore, covalent binding with serum albumin appeared to be decreased in the presence of glutathione.

Keywords

Glutathione High Pressure Liquid Chromatography Covalent Binding Anilide Sulfamides 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • H. De Vries
    • 1
  • G. M. J. Beijersbergen Van Henegouwen
    • 1
  1. 1.Subfaculty of Pharmacy, Department of PharmacochemistryState UniversityRA LeidenThe Netherlands

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