Effect of chloroquine on hepatic triacylglycerol metabolism
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Chloroquine, a lysosomotropic agent, has been found to be a potent inhibitor of hydrolysis of triacylglycerol stores in isolated hepatocytes from starved donor rats. It significantly inhibits the disappearance of radioactivity from prelabelled triacylglycerols and the appearance of label in acid-soluble products. Furthermore, it inhibits oxidation and stimulates esterification of added oleate.
KeywordsOleate Chloroquine Fatty Acid Oxidation Triacylglycerol Lipase Pharmaceutisch Weekblad Scientific Edition
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- Bochner, F., G. Garruthers, J. Kampmann andJ. Steiner (1978)Handbook of Clinical Pharmacology. Little, Brown and Company, Boston, 127.Google Scholar