Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 820–822 | Cite as

Inhibition of cholesterol synthesis in isolated rat hepatocytes by salicylate

  • A. C. Beynen
  • A. J. Van Der Molen
  • M. J. H. Geelen
Short Communications


Salicylate has been found to be an inhibitor of cholesterol biosynthesis by isolated hepatocytes. Half maximal inhibition of cholesterogenesis occurs at approximately 7.5 mmol/l salicylate. It is proposed that salicylate, at blood levels encountered therapeutically, inhibits hepatic cholesterol synthesis.


Salicylate Chloroquine Cholesterol Synthesis Rheumatic Fever Sodium Salicylate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Beynen, A. C., W. J. Vaartjes andM. J. H. Geelen (1979)Diabetes 28, 828.CrossRefPubMedGoogle Scholar
  2. Brunengraber, H., J. R. Sabine, M. Boutry andJ. M. Lowenstein (1972)Arch. Biochem. Biophys. 150, 392.CrossRefPubMedGoogle Scholar
  3. Harris, R. A. (1975)Arch. Biochem. Biophys. 169, 168.CrossRefPubMedGoogle Scholar
  4. Hart, F. D. (1976)Drug Treatment. Principles and practice of clinical pharmacology and therapeutics (Avery, G. S., Ed.). Adis Press, Sydney-New York, 624.Google Scholar
  5. Klimov, A. N., O. K. Dokusova, L. A. Petrova andE. D. Poliakova (1971)Biochem. Pharmacol. 20, 227.CrossRefPubMedGoogle Scholar
  6. Klimov, A. N., O. K. Dokusova andE. D. Poliakova (1969)Biochem. Pharmacol. 18, 1251.CrossRefPubMedGoogle Scholar
  7. Lowry, O. H., N. J. Rosebrough, A. L. Farr andR. J. Randall (1951)J. Biol. Chem. 193, 265.PubMedGoogle Scholar
  8. Pennial, R., G. Kalnitsky andJ. I. Routh (1956)Arch. Biochem. Biophys. 64, 390.CrossRefGoogle Scholar
  9. Reid, J. (1961) cited byKlimov et al. (1969), 1251.Google Scholar
  10. Sabine, J. R. (1977)Cholesterol. Marcel Dekker Inc., New York, 79.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • A. C. Beynen
    • 1
  • A. J. Van Der Molen
    • 1
  • M. J. H. Geelen
    • 1
  1. 1.Laboratory of Veterinary BiochemistryState University of UtrechtBP UtrechtThe Netherlands

Personalised recommendations