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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 789–799 | Cite as

The interference of light in pharmacotherapy

  • G. M. J. Beijersbergen Van Henegouwen
Review Articles
  • 13 Downloads

Abstract

Although human photobiology is not yet studied very extensively, some responses to light such as the sunburn syndrome and the formation of vitamin D3 are wellknown. These processes indicate a profound influence of light on the human body. It is therefore remarkable that within pharmaceutical sciences so little attention has been paid to a possible interference of drugs in this subtle balance between light and the human body. After dealing with some photochemical and photobiological facts, drugs are reviewed of which adverse and beneficial effects in combination with light are reported by dermatologists. The research data which give an explanation of these effects on molecular level, although being scarce, allow the conclusion that light is an important factor in the research of drug action. Deeper insight into this factor can lead to a maximum of the wanted pharmacological activity with a minimum of side effects caused by light but also to the design of phototherapeutic drugs. The article concludes with an example of research which demonstrates the usefulness of taking light into account as an environmental factor in drug research.

Keywords

Nitrazepam Norethisterone Neonatal Jaundice PUVA Therapy Urocanic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • G. M. J. Beijersbergen Van Henegouwen
    • 1
  1. 1.Dept. of Pharmacochemistry, Subfaculty of PharmacyState University of Leiden, Gorlaeus LaboratoriesRA LeidenThe Netherlands

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