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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 789–799 | Cite as

The interference of light in pharmacotherapy

  • G. M. J. Beijersbergen Van Henegouwen
Review Articles
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Abstract

Although human photobiology is not yet studied very extensively, some responses to light such as the sunburn syndrome and the formation of vitamin D3 are wellknown. These processes indicate a profound influence of light on the human body. It is therefore remarkable that within pharmaceutical sciences so little attention has been paid to a possible interference of drugs in this subtle balance between light and the human body. After dealing with some photochemical and photobiological facts, drugs are reviewed of which adverse and beneficial effects in combination with light are reported by dermatologists. The research data which give an explanation of these effects on molecular level, although being scarce, allow the conclusion that light is an important factor in the research of drug action. Deeper insight into this factor can lead to a maximum of the wanted pharmacological activity with a minimum of side effects caused by light but also to the design of phototherapeutic drugs. The article concludes with an example of research which demonstrates the usefulness of taking light into account as an environmental factor in drug research.

Keywords

Nitrazepam Norethisterone Neonatal Jaundice PUVA Therapy Urocanic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ames, B. N., J. Mccann andE. Yamasaki (1975)Mutat. Res. 31, 347–364.CrossRefPubMedGoogle Scholar
  2. Bakri, A., andG. M. J. Beijersbergen Van Henegouwen (1981) Part of a Ph.D. thesis to be published.Google Scholar
  3. Bland, J. (1976)J. Chem. Educ. 53, 274–279.CrossRefGoogle Scholar
  4. Bridges, B., andG. Strauss (1980)Nature 283, 523–524.CrossRefPubMedGoogle Scholar
  5. Clayton, R. K. (1971)Light and living matter, Vol. 2. Mac-Graw-Hill, New York, ch. 5.Google Scholar
  6. Cornelissen, P. J. G. (1980) Ph.D. thesis, Leiden.Google Scholar
  7. Cornelissen, P. J. G., andG. M. J. Beijersbergen Van Henegouwen (1979)Photochem. Photobiol. 30, 337–341.CrossRefGoogle Scholar
  8. Cornelissen, P. J. G., andG. M. J. Beijersbergen Van Henegouwen (1980)Pharm. Weekblad Sci. Ed. 2, 39–48.Google Scholar
  9. Cornelissen, P. J. G., andG. M. J. Beijersbergen Van Henegouwen (1981)Pharm. Weekblad Sci. Ed. 3, 96–105.Google Scholar
  10. Cornelissen, P. J. G., G. M. J. Beijersbergen Van Henegou-Wen andK. W. Gerritsma (1979)Int. J. Pharm. 3, 205–220.CrossRefGoogle Scholar
  11. Cornelissen, P. J. G., G. M. J. Beijersbergen Van Henegouwen andG. R. Mohn (1981)Photochem. Photobiol., in press.Google Scholar
  12. Emmett, E. A. (1979)Photochem. Photobiol. 30, 429–436.CrossRefPubMedGoogle Scholar
  13. Epstein, J. H. (1977) In:Science of photobiology (Smith, K. C., Ed.). Plenum Press, New York, ch. 7.Google Scholar
  14. Epstein, J. H. (1979)New Engl. J. Med. 300, 852–853.CrossRefPubMedGoogle Scholar
  15. Everett, M. A. (1966)Photochem. Photobiol. 5, 533–542.CrossRefPubMedGoogle Scholar
  16. Fitzpatrick, T. B., M. A. Pathak, L. C. Harber, M. Seiji andA. Kukita (1974) In:Sunlight and man (Fitzpatrick, T. B.,et al., Eds.). University of Tokyo Press, Tokyo, ch. 1.Google Scholar
  17. Foote, C. S. (1976) In:Free Radicals Biol. (Pryor, W. A., Ed.). Vol. 2, Academic Press, New York, 85–113.CrossRefGoogle Scholar
  18. Giese, A. C. (1976) In:Living with our sun's ultraviolet rays. Plenum Press, New York, ch. 3 and ch. 5.CrossRefGoogle Scholar
  19. Gutter, B., W. T. Spek andH. S. Rosenkranz (1977a)Cancer Res. 37, 112–114;Ibidem (1977b)Mut. Res. 44, 177–182.Google Scholar
  20. Jarratt, M. (1976)Int. J. Dermatol. 15, 317–325.CrossRefPubMedGoogle Scholar
  21. Johnson, B. E. (1974)Proc. Roy. Soc. Med. 67, 871.PubMedPubMedCentralGoogle Scholar
  22. Jose, J. G. (1979)Proc. Natl. Acad. Sci. USA 76, 469–472.CrossRefPubMedPubMedCentralGoogle Scholar
  23. Khan, U. A. (1976)J. Phys. Chem. 80, 2219–2228.CrossRefGoogle Scholar
  24. Langner, A., H. Wolska, M. A. Chorlzelska andM. Pawinska (1975)J. Invest. Dermatol. 64, 279–280.Google Scholar
  25. Ljunggren, B., andH. Möller (1977)J. Invest. Dermatol. 68, 313–317;Ibidem (1978)Acta Dermato-Venereol. 58, 125–130.CrossRefPubMedGoogle Scholar
  26. Magnus, I. A. (1976)Dermatological photobiology. Blackwell, London, ch. 16.Google Scholar
  27. Mccann, J., E. Choi, E. Yamasaki andB. N. Ames (1975)Proc. Natl. Acad. Sci. USA 72, 35–39.Google Scholar
  28. Meisel, P., D. Jährig andK. Jährig (1980)Pharmazie 35, 377–389.PubMedGoogle Scholar
  29. Mol, N. J. De (1980)Involvement of molecular singlet oxygen in the photosensitizing action of furocoumarins. Ph.D. thesis, Leiden.Google Scholar
  30. Mol, N. J. De, andG. M. J. Beijersbergen Van Henegouwen (1979)Photochem. Photobiol. 30, 331–335.CrossRefGoogle Scholar
  31. Mol, N. J. De, andG. M. J. Beijersbergen Van Henegouwen (1981)Photochem. Photobiol. 33, 815–820.CrossRefPubMedGoogle Scholar
  32. Mol, N. J. De, G. M. J. Beijersbergen Van Henegouwen andB. Van Beele (1981a)Photochem. Photobiol., in press.Google Scholar
  33. Mol, N. J. De, G. M. J. Beijersbergen Van Henegouwen, G. R. Mohn andP. M. Van Kleef (1981b)Mut. Res. 82, 23–30.CrossRefGoogle Scholar
  34. Moore, D. E. (1977)J. Pharm. Sci. 66, 1282–1284.CrossRefPubMedGoogle Scholar
  35. Musajo, L., andG. Rodighiero (1972) In:Photophysiology (Giese, A. C., Ed.), Vol. VII. Academic Press, New York, ch. 5.Google Scholar
  36. Parrish, J. A., T. B. Fitzpatrick, C. Shea andM. A. Pathak (1976)Arch. Dermatol. 112, 1531–1534.CrossRefPubMedGoogle Scholar
  37. Rosenthal, I., E. Ben-Hur, A. Prager andE. Riklis (1978)Photochem. Photobiol. 28, 591–594.CrossRefPubMedGoogle Scholar
  38. Sedée, A. G. J. (1981) Part of an Ph.D. thesis to be published.Google Scholar
  39. Smith, K. C. (1977) In:Science of Photobiology (Smith, K. C., Ed.) Plenum Press, New York, ch. 15.CrossRefGoogle Scholar
  40. Spikes, J. D., andB. W. Glad (1964)Photochem. Photobiol. 3, 471–487.CrossRefGoogle Scholar
  41. Stern, R. S. (1979)New Engl. J. Med. 300, 809–813.CrossRefPubMedGoogle Scholar
  42. Theodoridis, A., D. Tsamboas, C. Sivenas andJ. Capetanakis (1976)Acta Dermato-Venereol. 56, 253–256.Google Scholar
  43. Widmer, O., K. Zürcher andA. Krebs (1976)Dermatologica 152, 216–253.CrossRefGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • G. M. J. Beijersbergen Van Henegouwen
    • 1
  1. 1.Dept. of Pharmacochemistry, Subfaculty of PharmacyState University of Leiden, Gorlaeus LaboratoriesRA LeidenThe Netherlands

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