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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 595–597 | Cite as

Remarks on the structure-activity relationship of some antibacterial silver non-sulfanilamide compounds

  • A. Bult
  • B. L. Bajema
  • H. B. Klasen
  • H. J. Metting
  • Ch. L. FoxJr.
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Abstract

In this study some physical parameters of a number of silver non-sulfanilamide compounds (acetate, 4-nitrobenzoate, nitrate, salicylate and 2-thiosalicylate) and silver sulfadiazine are related to the antibacterialin vivo activity of these compounds. The stability constant and solubility are important factors in the development of the biological activity and the mechanism of action (active as silver ion or the whole molecule).

Keywords

Salicylate AgNO3 Stability Constant Sulfadiazine Silver Salt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • A. Bult
    • 1
  • B. L. Bajema
    • 1
  • H. B. Klasen
    • 1
  • H. J. Metting
    • 1
  • Ch. L. FoxJr.
    • 2
  1. 1.Laboratory for Pharmaceutical and Analytical ChemistryState UniversityAW GroningenThe Netherlands
  2. 2.College of Physicians and Surgeons, Department of Surgery and MicrobiologyColumbia UniversityNew YorkUSA

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