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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 245–251 | Cite as

Challenge testing — The laboratory evaluation of the preservation of pharmaceutical preparations

  • D. F. Spooner
  • B. Croshaw
Voordrachten
  • 52 Downloads

Abstract

The need for adequate preservation and the difficulties of definition and testing are outlined and pharmacopoeial challenge tests are compared. While similar in principle they differ in detail and in the interpretation of results. The USP test is intended for multi-dose sterile products but BP and draft EP tests include also criteria for topical and liquid oral preparations. Those of the BP, based on the performance of established well-preserved BP preparations, are not mandatory but provide guidance for the selection of suitable antimicrobial preservatives for inclusion in formulae of the Pharmacopoeia.

Keywords

Challenge Test Sodium Cromoglycate United States Pharmacopeia British Pharmacopoeia Cosmetic Chemist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • D. F. Spooner
    • 1
  • B. Croshaw
    • 1
  1. 1.The Boots Company Ltd.NottinghamEngland

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