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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 238–242 | Cite as

Acute renal insufficiency after change from chlorthalidone to tienilic acid

  • J. J. M. Van Bussel
  • B. B. A. Laemers
  • K. H. Peuker
  • P. Boer
  • E. J. Dorhout Mees
  • G. G. Geyskes
Short Communications

Abstract

In an in-hospital study, 3 out of 5 patients with essential hypertension on continuous chlorthalidone treatment developed reversible renal insufficiency when chlorthalidone was replaced by tienilic acid. In a control group of 6 patients, tienilic acid after placebo was not followed by renal insufficiency. Since the urinary uric acid concentration and the uric acid/creatinine ratio was not higher in the patients who developed renal insufficiency than in the control group, the drug interaction probably cannot be explained by uric acid nephropathy.

Keywords

Uric Acid Renal Insufficiency Chlorthalidone Uric Acid Concentration Phenoxy Acetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • J. J. M. Van Bussel
    • 1
  • B. B. A. Laemers
    • 1
  • K. H. Peuker
    • 2
  • P. Boer
    • 3
  • E. J. Dorhout Mees
    • 3
  • G. G. Geyskes
    • 3
  1. 1.Department of PharmacotherapyUniversity of UtrechtThe Netherlands
  2. 2.Department of Clinical BiochemistryUniversity HospitalUtrecht
  3. 3.Department of Nephrology and HypertensionUniversity HospitalGV UtrechtThe Netherlands

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