Acute renal insufficiency after change from chlorthalidone to tienilic acid
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In an in-hospital study, 3 out of 5 patients with essential hypertension on continuous chlorthalidone treatment developed reversible renal insufficiency when chlorthalidone was replaced by tienilic acid. In a control group of 6 patients, tienilic acid after placebo was not followed by renal insufficiency. Since the urinary uric acid concentration and the uric acid/creatinine ratio was not higher in the patients who developed renal insufficiency than in the control group, the drug interaction probably cannot be explained by uric acid nephropathy.
KeywordsUric Acid Renal Insufficiency Chlorthalidone Uric Acid Concentration Phenoxy Acetic Acid
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