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One-bond carbon-proton coupling constants: Angular dependence in β-linked oligosaccharides

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Summary

The angular dependence of1JC,H in model compounds related to β-linked oligosaccharides has been established by FPT INDO quantum chemical calculations. Values calculated for models of (1 → 1)-, (1 → 2)-, (1 → 3)- and (1 → 4)-linked disaccharides were compared, and the effect of the orientation of HO-2 elucidated. The angular dependence of1JC,H on the torsional angles ΦH and ΨH and the solvent dielectric constant (s) was characterized in the form:1JC,H = A cos2ϖ+B cosϖ + C sin2ϖ + D since + E + Fe. The1JC,H values, measured by DEPT methods for C-1-H-1 and C-X′-H-X′ in cellobiose, cyclic trisaccharide and hexopyranoses were used to adjust the calculated angular dependences. Based on the occurrence of the conformers for agarobiose, neoagarobiose, mannobiose and methyl β-xylobioside, the thermodynamically averaged <1JC,H > values were calculated. The results obtained (<1JC-1,H-1 > 162.4, <1JC-4′, H-4′ > 147.6 Hz for methyl β-xylobioside; <1JC-1,H-1 > 162.4 and <1JC-4′,H-4′] > 147.6 Hz for mannobiose; <1JC-1,H-1 > 162.8 Hz for neo agarobiose and <1JC-1,H-1 > 163.2 Hz for agarobiose) agree well with the experimental values of 162.7, 147.5, 160.4, 147.2, 160.9 and 165.7 Hz, respectively.

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Correspondence to François R. Taravel.

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Tvaroska, I., Taravel, F.R. One-bond carbon-proton coupling constants: Angular dependence in β-linked oligosaccharides. J Biomol NMR 2, 421–430 (1992). https://doi.org/10.1007/BF02192806

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Keywords

  • One-bond carbon-proton coupling constants
  • β-Linked oligosaccharides
  • Angular dependence