Clinical symptoms and regional cerebral blood flow in schizophrenia

  • Satoru Yuasa
  • Masayoshi Kurachi
  • Michio Suzuki
  • Youichi Kadono
  • Mié Matsui
  • Osamu Saitoh
  • Hikaru Seto
Original Paper


This study examined the relationship between clinical symptoms and regional cerebral blood flow (rCBF) in schizophrenic patients using single photon emission computed tomography (SPECT). The subjects were 26 medicated schizophrenic patients diagnosed according to DSM-III-R criteria. Clinical symptoms were assessed using the Scale for the Assessment of Negative Symptoms (SANS), selected items for the Positive and Negative Syndrome Scale (PANSS), and the scale for Schneider's first rank symptoms. Resting rCBF was measured using N-isopropyl-p-[I-123] iodoamphetamine (I-123 IMP) SPECT, and relative rCBF distribution was evaluated in nine regions of interest in each hemisphere. Factor analysis of symptom ratings indicated four separate syndromes: psychomotor poverty, alienation (hallucination and disturbance of the self), delusion, and disorganization. Stepwise multiple regression analysis showed the psychomotor poverty syndrome to be correlated with decreased rCBF in bilateral superior frontal areas and increased rCBF in the left thalamus and right basal ganglia. The disorganization syndrome was correlated with increases rCBF in bilateral anterior cingulates and decreased rCBF in bilateral midolle frontal areas. The alienation syndrome was shown related to increased rCBF in the right inferior frontal area and parietal area. Dysfunction in distinctive neural networks involving various prefrontal areas would thus appear to underlie these syndromes in schizophrenia.

Key words

SPECT Regional cerebral blood flow Clinical symptoms Stepwise multiple regression Schizophrenia 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Satoru Yuasa
    • 1
  • Masayoshi Kurachi
    • 1
  • Michio Suzuki
    • 1
  • Youichi Kadono
    • 1
  • Mié Matsui
    • 1
  • Osamu Saitoh
    • 1
  • Hikaru Seto
    • 2
  1. 1.Department of NeuropsychiatryToyama Medical and Pharmaceutical UniversityToyamaJapan
  2. 2.Department of RadiologyToyama Medical and Pharmaceutical UniversityToyamaJapan

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