Molecular and General Genetics MGG

, Volume 248, Issue 4, pp 491–498

A fission yeast gene mapping close tosuc1 encodes a protein containing two bromodomains

  • Stephen J. Aves
  • John Hindley
  • Geraldine A. Phear
  • Nicholas Tongue
Original Paper


A novel gene,brd1, has been cloned from the fission yeastSchizosaccharomyces pombe. The predictedbrd1 product contains two copies of an imperfect repeat of 96 amino acid residues in its N-terminal half. These each include a region with high homology to the bromodomains found in transcriptional activator proteins from a diversity of eukaryotes. An in vivo deletion of the completebrd1 open reading frame is not lethal but cells exhibit thermosensitivity, with reductions in both cell growth and stationary phase survival at 36°C.brd1 maps adjacent to the genesuc1, but is expressed separately to give a low abundance 2.1 kb mRNA.

Key words

Schizosaccharomyces pombe Bromodomain Transcriptional activation Coactivator Stationary phase 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Stephen J. Aves
    • 1
  • John Hindley
    • 2
  • Geraldine A. Phear
    • 2
  • Nicholas Tongue
    • 1
  1. 1.Department of Biological SciencesUniversity of Exeter, Washington Singer LaboratoriesExeterUK
  2. 2.Department of BiochemistryUniversity of BristolBristolUK
  3. 3.Department of RadiologyEccles Institute of Human Genetics, University of UtahSalt Lake CityUSA

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