European Journal of Pediatrics

, Volume 154, Supplement 4, pp S60–S64

Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity

  • P. Imbach
  • J. Akatsuka
  • V. Blanchette
  • A. Burek-Kozlowska
  • J. Bussel
  • G. Gaedicke
  • A. Gianella-Borradori
  • E. Gugler
  • A. Hirt
  • B. Imholz
  • R. McMillan
  • A. Morell
  • A. Newland
  • D. Nugent
  • M. H. Schöni
  • H. P. Wagner
Living Pediatrics Symposium in Honour of the 80th Birthday of Professor E. Rossi, Berne, Switzerland


In honour of Professor Rossi's 80th birthday we review the development of our understanding of the immune and auto-immune nature of the pathogenesis of immune thrombocytopenic purpura (ITP). The immune aspects have been documented by postviral alterations of the cellular and humoral immune system, by new methods of specific auto-antibody detection against platelet glycoproteins and by the therapeutic effect of administering immunoglobulin concentrate from healthy blood donors. The various possible mechanisms of action of immunoglobulin treatment have led to use of this treatment as an alternative for other immune-related disorders. The treatment of severe chronic ITP in children, however, remains unsatisfactory. With a new international clinical and laboratory study of children and adolescents with early chronic ITP we are continuing the investigation of the pathogenesis and treatment of ITP.

Key words

Immune thrombocytopenic purpura Auto-antibodies Against platelets Immunoglobulin 



immune thrombocytopenic purpura


intravenous immunoglobulin


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • P. Imbach
    • 1
    • 2
  • J. Akatsuka
    • 3
  • V. Blanchette
    • 4
  • A. Burek-Kozlowska
    • 5
  • J. Bussel
    • 6
  • G. Gaedicke
    • 7
  • A. Gianella-Borradori
    • 8
  • E. Gugler
    • 9
  • A. Hirt
    • 9
  • B. Imholz
    • 9
  • R. McMillan
    • 10
  • A. Morell
    • 5
  • A. Newland
    • 11
  • D. Nugent
    • 12
  • M. H. Schöni
    • 13
  • H. P. Wagner
    • 9
  1. 1.Kinderklinik AarauAarauSwitzerland
  2. 2.Universitäts-KinderspitalBaselSwitzerland
  3. 3.The Daisan HospitalTokyoJapan
  4. 4.Hospital for Sick ChildrenToronto 10Canada
  5. 5.Central LaboratorySRKBerneSwitzerland
  6. 6.Cornell UniversityNew YorkUSA
  7. 7.Universitäts-Kinderklinik CharlottenburgBerlinGermany
  8. 8.SandozBaselSwitzerland
  9. 9.Kinderklinik InselspitalBernSwitzerland
  10. 10.Scripps ClinicLa JollaU.S.A.
  11. 11.The London HospitalLondonU.K.
  12. 12.Children's HospitalOrangeUSA
  13. 13.Alpine Children's HospitalDavosSwitzerland

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