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Platelet imipramine binding in intensive care unit suicidal patients


3H-Imipramine binding in relation to serotonergic function was studied in patients hospitalized following a suicide attempt. Comparison with a control group showed a highly significant difference in Bmax values. The results suggest, at least a posteriori, a biological alteration as the basis of suicidal behaviour. Although it is impossible to attribute a suicidal attempt to the alteration or to a predisposing pre-existent condition, this biological marker may be useful in evaluating suicidal risk and also short- and long-term prognosis.

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De Leo, D., Caneva, A., Marazziti, D. et al. Platelet imipramine binding in intensive care unit suicidal patients. Eur Arch Psychiatry Clin Nuerosci 241, 85–87 (1991). https://doi.org/10.1007/BF02191146

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Key words

  • 3H-Imipramine binding sites
  • Attempted suicide
  • Biology of suicide