3H-Imipramine binding in relation to serotonergic function was studied in patients hospitalized following a suicide attempt. Comparison with a control group showed a highly significant difference in Bmax values. The results suggest, at least a posteriori, a biological alteration as the basis of suicidal behaviour. Although it is impossible to attribute a suicidal attempt to the alteration or to a predisposing pre-existent condition, this biological marker may be useful in evaluating suicidal risk and also short- and long-term prognosis.
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Asberg M, Bertilsson L, Martensson B (1984) CSF monoamine metabolites depression, and suicide. In Frontiers in Biochemical and Pharmachological Research in Depression, Usdin E, Asberg M, Bertilsson L et al. (eds), Raven Press, New York
Praag HM Van, Haan S de (1979) Central serotonin metabolism and the frequency of depression. Psychiatry Res, 1:219–224
Weissman M, Fox K, Lerman GL (1973) Hostility and depression associated with suicide attempts. Am J Psychiatry, 130:450–455
Stanley M, Stanley B (1990) Postmortem evidence for serotonin's role in suicide. J Clin Psychiatry, 51:22–28
Sthal SM (1977) The human platelet: a diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Arch Gen Psychiatry, 34:509–516
Langer SZ, Raisman R, Briley MS et al. (1980) Platelets from depressed patients have a decreased number of 3H-Imipramine binding sites. Federal Proceedings, 30:1097–1102
Langer SZ, Raisman R (1983) High-affinity binding of 3H-imipramine and 3H-desipramine: Biochemical tools for studies in depression. Life Sci 29:211–220
Waegner A, Asberg-Wistedt A, Asberg M et al. (1985) Lower 3H-imipramine binding in platelets from untreated depressed patients compared to healthy controls. Psychiatry Res 16:131–139
Roy A, Everett D, Pickar D et al. (1987) Platelet tritiated imipramine binding and serotonin uptake in depressed patients and controls. Relationship to plasma cortisol levels before and after dexamethasone administration. Arch Gen Psychiatry 44(4):320–327
WHO (1983) Collaborative study on the validity of the 3H-Imipramine platelet binding sites as a biological marker of endogenous depression. Technical Report
Peterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem, 83:346–352
De Leo D, Marazziti D (1988) Biological prediction of suicide: The role of serotonin. Crisis, 9/2:109–118
Ieni JR, Zukin SR, Praag HM Van (1985) Human platelets possess multiple 3H-Imipramine binding sites. Eur J Pharmacol, 106:669–672
Mellerup ET, Plenge P (1988) Imipramine binding in depression and other psychiatric conditions. Acta Psychiatr Scand, 78 (Suppl 345):61–68
Mann JJ, Arango V, Marzuk PM et al. (1989) Evidence for the 5-HT Hypothesis of suicide. A review of post-mortem studies. Br J Psychiatry, 155:7–14.
Hawton K, Fagg J (1988) Suicide and other causes of death, following attempted suicide. Br J Psychiatry, 152:359–366
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De Leo, D., Caneva, A., Marazziti, D. et al. Platelet imipramine binding in intensive care unit suicidal patients. Eur Arch Psychiatry Clin Nuerosci 241, 85–87 (1991). https://doi.org/10.1007/BF02191146
- 3H-Imipramine binding sites
- Attempted suicide
- Biology of suicide