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Interferon for chronic hepatitis C in patients cured of malignancy

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Abstract

Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/m2 for 12 months; the post-treatment follow up period was 12 months. Therapy was stopped within 6 months in three patients because of persistently abnormal alanine aminotransferase levels. In the remaining three patients, a complete normalization of alanine amnotransferase levels was obtained during treatment but it was not maintained after the end of interferon therapy. In addition, no patient cleared hepatitis C virus ribonucleic acid in serum. These results suggest that recombinant interferon is not effective in patients with chronic hepatitis C who were cured of a previous malignancy.

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Abbreviations

ALT :

alanine aminotransferase

Anti-HCV :

hepatitis C virus antibodies

HBV :

hepatitis B virus

HCV :

hepatitis C virus

IFN :

recombinant interferonalpha

RIBA II :

recombinant immunoblotting assay second generation

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Cesaro, S., Rossetti, F., Zanesco, L. et al. Interferon for chronic hepatitis C in patients cured of malignancy. Eur J Pediatr 153, 659–662 (1994). https://doi.org/10.1007/BF02190687

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Key words

  • Chronic hepatitis
  • Hepatitis C virus
  • Childhood malignancy
  • Recombinant interferon-alpha