Interferon for chronic hepatitis C in patients cured of malignancy
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Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/m2 for 12 months; the post-treatment follow up period was 12 months. Therapy was stopped within 6 months in three patients because of persistently abnormal alanine aminotransferase levels. In the remaining three patients, a complete normalization of alanine amnotransferase levels was obtained during treatment but it was not maintained after the end of interferon therapy. In addition, no patient cleared hepatitis C virus ribonucleic acid in serum. These results suggest that recombinant interferon is not effective in patients with chronic hepatitis C who were cured of a previous malignancy.
Key wordsChronic hepatitis Hepatitis C virus Childhood malignancy Recombinant interferon-alpha
hepatitis C virus antibodies
hepatitis B virus
hepatitis C virus
- RIBA II
recombinant immunoblotting assay second generation
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