European Journal of Pediatrics

, Volume 153, Issue 8, pp 607–610 | Cite as

Mercury burden of human fetal and infant tissues

  • G. Drasch
  • I. Schupp
  • H. Höfl
  • R. Reinke
  • G. Roider
Original Paper


The total mercury concentrations in the liver (Hg-L), the kidney cortex (Hg-K) and the cerebral cortex (Hg-C) of 108 children aged 1 day-5 years, and the Hg-K and Hg-L of 46 fetuses were determined. As far as possible, the mothers were interviewed and their dental status was recorded. The results were compared to mercury concentrations in the tissues of adults from the same geographical area. The Hg-K (n = 38) and Hg-L (n = 40) of fetuses and Hg-K (n = 35) and Hg-C (n = 35) of older infants (11–50 weeks of life) correlated significantly with the number of dental amalgam fillings of the mother. The toxicological relevance of the unexpected high Hg-K of older infants from mothers with higher numbers of dental amalgam fillings is discussed.

Key words

Mercury Fetuses Newborns Infants Dental amalgam 



total mercury concentration in the cerebral cortex (ng/g wet weight)


total mercury concentration in the renal cortex (ng/g wet weight)


total mercury concentration in the liver (ng/g wet weight)


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  1. 1.
    Aposhian HV, Bruce DC, Alter W, Dart RC, Hurlbut KM, Aposhian MM (1992) Urinary mercury after administration of 2,3-dimercaptopropane-l-sulfonic acid: correlation with dental amalgam score. FASEB J 6: 2472–2476Google Scholar
  2. 2.
    Boyd ND, Benediktsson H, Vimy MJ, Hooper DE, Lorscheider FL (1991) Mercury from dental “silver” tooth fillings impairs sheep kidney function. Am J Physiol 261: R 1010-R 1014Google Scholar
  3. 3.
    Bundesgesundheitsamt (1992). bga-Informationsschrift “Amalgame in der zahnärztlichen Therapie”. BerlinGoogle Scholar
  4. 4.
    Drasch G, Kretschmer E, Neidlinger P, Summer KH (1989) Cadmium, zinc, copper and methallothionein in human tissues (liver and kidney). Toxicol Environ Chem 23: 207–214Google Scholar
  5. 5.
    Drasch G, Schupp I, Riedl G, Günther G (1992) Einfluß von Amalgamfüllungen auf die Quecksilberkonzentration in menschlichen Organen. Dtsch Zahnärztl Z 47: 490–496Google Scholar
  6. 6.
    Goering PL, Galloway WD, Clarkson TW, Lorscheider FL, Berlin M, Rowland AS (1992) Toxicity assessment of mercury vapor from dental amalgams. Fund Appl Toxicol 19: 319–329Google Scholar
  7. 7.
    Horvat M, Stegnar P, Byrne AR, Dermelj M, Branica Z (1988) A study of trace elements in human placenta, blood and hair from the yugoslav central adriatic. In: Brätter P, Schramel P (eds) Trace elements analytical chemisty in medicine and biology, vol. 5. de Gruyter, Berlin, pp 243–250Google Scholar
  8. 8.
    Klein D, Scholz P, Drasch G, Müller-Höcker J, Summer KH (1991) Metallothionein, copper and zinc in fetal and neonatal human liver: changes during development. Toxicol Lett 56: 61–67Google Scholar
  9. 9.
    Klemann D, Weinhold J, Strubelt O, Pentz R, Jungblut JR, Kleik F (1990) Der Einfluß von Amalgamfüllungen auf die Quecksilberkonzentrationen in Fruchtwasser und Muttermilch. Dtsch Zahnärztl Z 45: 142–145Google Scholar
  10. 10.
    Koos BJ, Longo LD (1976) Mercury toxicity in the pregnant woman, fetus and newborn infant. Am J Obstet Gynecol 126: 390–409Google Scholar
  11. 11.
    Larsson KS (1991) Tereatological aspects of dental amalgam. Adv Dent Res 6: 114–119Google Scholar
  12. 12.
    Larsson KS, Sagulin G-B (1990) Placental transfer of mercury from amalgam. Lancet 336: 1251Google Scholar
  13. 13.
    Lorscheider FL, Vimy MJ (1990) Mercury from dental amalgam. Lancet 336: 1578–1579Google Scholar
  14. 14.
    Markesbery WR, Ehmann WD, Alauddin M, Hussain TIM (1984) Brain trace element concentration in aging. Neurobiol Aging 5: 19–28Google Scholar
  15. 15.
    Mottet NK, Body RL (1974) Mercury burden of human autopsy organs and tissues. Arch Environ Health 29: 18–24Google Scholar
  16. 16.
    Nishimura H, Hirota S, Tannaka O, Ueda M, Uno T (1974) Normal mercury level in human embryos and fetuses. Biol Neonate 24: 197–205Google Scholar
  17. 17.
    Nordberg GF (1989) Modulation of metal toxicity by metallothionein. Biol Trace Elem Res 21: 131–135Google Scholar
  18. 18.
    Nylander M, Weiner J (1991) Mercury and selenium concentrations and their inter-relationship in organs from dental staff and the general population. Br J Ind Med 48: 729–734Google Scholar
  19. 19.
    Schupp I (1994) Untersuchungen an menschlichen Organen zur Frage der Quecksilberbelastung durch Zahnamalgam und weitere Faktoren. Dissertation, München, F.R.G.Google Scholar
  20. 20.
    Suzuki T, Yonemoto J, Satoh H, Naganuma A, Imura N, Kigawa T (1984) Normal organic and inorganic mercury levels in the human feto-placental system. J Appl Toxicol 4: 249–252Google Scholar
  21. 21.
    Thorp JM, Boyette DD, Watson WJ, Cefalo RC (1992) Elemental mercury exposure in early pregnancy. Obstet Gynecol 79: 874–876Google Scholar
  22. 22.
    Vimy MJ, Takahashi, Y, Lorscheider FL (1990) Maternal-fetal distribution of mercury (203Hg) released from dental amalgam fillings. Am J Physiol 258: R939-R945Google Scholar
  23. 23.
    Von Mühlendahl KE (1990) Intoxication from mercury spilled on carpets. Lancet 336: 1578Google Scholar
  24. 24.
    WHO (1991) Environmental Health Criteria 118: Inorganic Mercury. World Health Organization, GenevaGoogle Scholar
  25. 25.
    Yoshida M, Aoyama H, Satoh H, Yamamura Y (1987) Binding of mercury to metallothionein-like protein in fetal liver of the guinea pig following inutero exposure to mercury vapor. Toxicol Lett 37: 1–6Google Scholar
  26. 26.
    Yoshida M, Satoh H, Kojima S, Yamamura Y (1989) Distribution of mercury in neonatal guinea-pigs after the exposure to mercury vapours. Bull Environ Contam Toxicol 43: 697–704Google Scholar
  27. 27.
    Zinke T (1992) Amalgame in der zahnärztlichen Therapie. Bundesgesundhbl 35:613–616Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • G. Drasch
    • 1
  • I. Schupp
    • 1
  • H. Höfl
    • 1
  • R. Reinke
    • 1
  • G. Roider
    • 1
  1. 1.Institut für RechtsmedizinMünchenGermany

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